Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HMGCR | P04035 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | ACLY | P53396 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL8015717 | 0.98 | ALDH1A1 (0.65) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL27660948 | 0.96 | ALDH1A1 (0.62) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL384976 | 0.95 | ALDH1A1 (0.68) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL27890932 | 0.95 | ALDH1A1 (0.68) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL6118461 | 0.95 | ALDH1A1 (0.68) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL9538173 | 0.93 | ALDH1A1 (0.65) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL29157615 | 0.93 | ALDH1A1 (0.65) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL1146498 | 0.93 | ALDH1A1 (0.65) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL28868894 | 0.93 | ALDH1A1 (0.65) | ALDH1A1TSHRLMNAMEN1KMT2A | |
| Citric Acid SCHEMBL2820103 | 0.93 | ALDH1A1 (0.65) | ALDH1A1TSHRLMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 97 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114635282-B | Preparation method of flexible electromagnetic shielding material based on two-dimensional titanium carbide and aramid fiber compounding | 江苏新视界先进功能纤维创新中心有限公司 | 2024-12-24 | — | — | CN | claimed |
| CN-117770434-A | Anti-fatigue and immunity-improving composite probiotics fermentation liquor and preparation method and application thereof | 河北一然生物科技股份有限公司 | 2024-03-29 | — | — | CN | claimed |
| CN-111286789-B | Complex enzyme degumming agent and degumming method | 四川玉竹麻业有限公司 | 2022-11-15 | — | — | CN | claimed |
| CN-114635282-A | Preparation method of flexible electromagnetic shielding material based on two-dimensional titanium carbide (MXene) and aramid fiber composite | 江苏新视界先进功能纤维创新中心有限公司 | 2022-06-17 | — | — | CN | claimed |
| CN-114621304-A | Process for extracting gastrodin | 西藏天虹科技股份有限责任公司 | 2022-06-14 | — | — | CN | claimed |
| CN-113504315-A | Detection method of 2,4,5, 6-tetraaminopyrimidine sulfate | 北京斯利安药业有限公司 | 2021-10-15 | — | — | CN | claimed |
| CN-112391057-A | Color-changing edible food packaging film and preparation method thereof | 嘉兴市轩禾园艺技术有限公司 | 2021-02-23 | — | — | CN | claimed |
| CN-112250912-A | Degradable packaging film and preparation method thereof | 杭州鹿扬科技有限公司 | 2021-01-22 | — | — | CN | claimed |
| CN-108358887-B | Synthesis of optically pure sulfur-containing quaternary heterocyclic drug intermediate | 富乐马鸿凯（大连）医药有限公司 | 2020-12-22 | — | — | CN | claimed |
| CN-105078781-B | Papain dental gel composition for noninvasive treatment of dental caries and preparation method thereof | 布里克斯有限公司 | 2020-10-30 | — | — | CN | claimed |
| CN-111303656-A | Method for improving stability of mulberry red pigment | 江南大学 | 2020-06-19 | — | — | CN | claimed |
| CN-111286789-A | Complex enzyme degumming agent and degumming method | 四川玉竹麻业有限公司 | 2020-06-16 | — | — | CN | claimed |
| CN-107602883-B | Edible collagen membrane capable of regulating and controlling color and preparation method thereof | 四川大学 | 2020-04-28 | — | — | CN | claimed |
| CN-110692718-A | Gastrodia elata health-care yoghourt and preparation method thereof | 湖南省博世康中医药有限公司 | 2020-01-17 | — | — | CN | claimed |
| CN-103436502-B | Laccase modification method on basis of amino acid terminal amino group and application thereof | UNIV SOUTH CHINA TECH | 2015-03-11 | — | — | CN | claimed |
| CN-103436501-B | Laccase modification method on basis of amino acid terminal carboxyl group and application thereof | SOUTH CHINA UNIVERSITY OF TECHNOLOGY (CN) | 2014-10-08 | — | — | CN | claimed |
| CN-103436501-A | Laccase modification method on basis of amino acid terminal carboxyl group and application thereof | UNIV SOUTH CHINA TECH | 2013-12-11 | — | — | CN | claimed |
| CN-103436502-A | Laccase modification method on basis of amino acid terminal amino group and application thereof | UNIV SOUTH CHINA TECH | 2013-12-11 | — | — | CN | claimed |
| CN-101885925-B | Method for extracting brown pigment from oil-tea camellia husks | UNIV HANSHAN NORMAL | 2013-05-15 | — | — | CN | claimed |
| CN-101885925-A | Method for extracting brown pigment from oil-tea camellia husks | UNIV HANSHAN NORMAL | 2010-11-17 | — | — | CN | claimed |