Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.68 |
| ▸ | SLC13A5 | Q86YT5 | 6/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | BLM | P54132 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HMGCR | P04035 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | ACLY | P53396 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL3019359 | 0.95 | ALDH1A1 (0.68) | ALDH1A1SLC13A5TSHRLMNAMEN1 | |
| Citric Acid SCHEMBL384976 | 0.95 | ALDH1A1 (0.68) | ALDH1A1SLC13A5TSHRLMNAMEN1 | |
| Citric Acid SCHEMBL28657879 | 0.93 | ALDH1A1 (0.65) | ALDH1A1SLC13A5TSHRLMNAMEN1 | |
| Citric Acid SCHEMBL29157615 | 0.93 | ALDH1A1 (0.65) | ALDH1A1SLC13A5TSHRLMNAMEN1 | |
| Citric Acid SCHEMBL28868894 | 0.93 | ALDH1A1 (0.65) | ALDH1A1SLC13A5TSHRLMNAMEN1 | |
| Citric Acid SCHEMBL9538173 | 0.93 | ALDH1A1 (0.65) | ALDH1A1SLC13A5TSHRLMNAMEN1 | |
| Citric Acid SCHEMBL1146498 | 0.93 | ALDH1A1 (0.65) | ALDH1A1SLC13A5TSHRLMNAMEN1 | |
| Citric Acid SCHEMBL8015717 | 0.93 | ALDH1A1 (0.65) | ALDH1A1SLC13A5TSHRLMNAMEN1 | |
| Citric Acid SCHEMBL2820103 | 0.93 | ALDH1A1 (0.65) | ALDH1A1SLC13A5TSHRLMNAMEN1 | |
| Citric Acid SCHEMBL28148628 | 0.93 | ALDH1A1 (0.65) | ALDH1A1SLC13A5TSHRLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110079864-A | A kind of method that organic acid calcium salt prepares organic acid and calcium sulfate crystal whiskers by hydrochloric acid method | 哈尔滨工业大学（威海） | 2019-08-02 | — | — | CN | claimed |
| CN-106693043-A | Absorbable iron-base alloy implantable medical device and preparation method thereof | 先健科技(深圳)有限公司 | 2017-05-24 | — | — | CN | claimed |
| CN-103664569-B | Method for cleanly producing citric acid by coupling calcium salt method with precipitation displacement | INST PROCESS ENG CAS | 2015-07-01 | — | — | CN | claimed |
| CN-103664569-A | Method for cleanly producing citric acid by coupling calcium salt method with precipitation displacement | INST PROCESS ENG CAS | 2014-03-26 | — | — | CN | claimed |
| CN-102476993-B | Preparation method of sodium citrate | ANHUI BBCA BIOCHEMICAL CO LTD | 2013-11-13 | — | — | CN | claimed |
| CN-101648864-B | Purification method of citric acid fermentation broth | ANHUI BBCA BIOCHEMICAL CO LTD | 2013-03-27 | — | — | CN | claimed |
| US-20120129135-A1 | NOVEL TYPE OF ANION-CONTAINING CALCIUM PHOSPHATE COMPOUND FOR DENTAL REMINERALIZATION | TAIPEI MEDICAL UNIVERSITY (TW) | 2012-05-24 | — | — | US | claimed |
| CN-101648864-A | Purification method of citric acid fermentation broth | ANHUI BBCA BIOCHEMICAL CO LTD | 2010-02-17 | — | — | CN | claimed |
| CN-110079864-A | A kind of method that organic acid calcium salt prepares organic acid and calcium sulfate crystal whiskers by hydrochloric acid method | 哈尔滨工业大学（威海） | 2019-08-02 | — | — | CN | disclosed |
| CN-106693043-A | Absorbable iron-base alloy implantable medical device and preparation method thereof | 先健科技(深圳)有限公司 | 2017-05-24 | — | — | CN | disclosed |
| US-9539445-B2 | Type of anion-containing calcium phosphate compound for dental remineralization | TAIPEI MEDICAL UNIVERSITY (TW) | 2017-01-10 | — | — | US | disclosed |
| CN-103664569-B | Method for cleanly producing citric acid by coupling calcium salt method with precipitation displacement | INST PROCESS ENG CAS | 2015-07-01 | — | — | CN | disclosed |
| CN-103664569-A | Method for cleanly producing citric acid by coupling calcium salt method with precipitation displacement | INST PROCESS ENG CAS | 2014-03-26 | — | — | CN | disclosed |
| CN-102476993-B | Preparation method of sodium citrate | ANHUI BBCA BIOCHEMICAL CO LTD | 2013-11-13 | — | — | CN | disclosed |
| CN-203075946-U | Reaction device for preparing calcium citrate | ANHUI BBCA BIOCHEMICAL CO LTD | 2013-07-24 | — | — | CN | disclosed |
| CN-101648864-B | Purification method of citric acid fermentation broth | ANHUI BBCA BIOCHEMICAL CO LTD | 2013-03-27 | — | — | CN | disclosed |
| US-20120129135-A1 | NOVEL TYPE OF ANION-CONTAINING CALCIUM PHOSPHATE COMPOUND FOR DENTAL REMINERALIZATION | TAIPEI MEDICAL UNIVERSITY (TW) | 2012-05-24 | — | — | US | disclosed |
| CN-101648864-A | Purification method of citric acid fermentation broth | ANHUI BBCA BIOCHEMICAL CO LTD | 2010-02-17 | — | — | CN | disclosed |