SCHEMBL30195075

SCHEMBL30195075

COc1ncncc1NS(=O)(=O)c1ccc(CC(C)C)cc1-c1ccc(Cn2ccnc2C(C)(C)C)c(F)c1

nearest known ligand 0.41

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PIK3CA P42336 9/20 0.41
AGTR2 P50052 7/20 0.40
EDNRA P25101 1/20 0.39
PIK3CD O00329 2/20 0.38
PIK3CB P42338 2/20 0.38
MTOR P42345 2/20 0.38
PIK3CG P48736 2/20 0.38
ABCB11 O95342 1/20 0.37
CYP3A4 P08684 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30195142 0.91 AGTR2 (0.42) PIK3CAAGTR2EDNRAABCB11CYP3A4
SCHEMBL30194978 0.91 AGTR2 (0.47) PIK3CAAGTR2EDNRAPIK3CDPIK3CB
SCHEMBL30195048 0.86 AGTR2 (0.42) PIK3CAAGTR2EDNRAABCB11CYP3A4
SCHEMBL30195170 0.85 AGTR2 (0.48) AGTR2CYP3A4
SCHEMBL30195009 0.84 AGTR2 (0.47) AGTR2CYP3A4
SCHEMBL30195030 0.84 AGTR2 (0.42) AGTR2EDNRACYP3A4
SCHEMBL30195090 0.84 AGTR2 (0.43) AGTR2CYP3A4
SCHEMBL30195087 0.83 AGTR2 (0.47) AGTR2CYP3A4
SCHEMBL30195053 0.83 AGTR2 (0.49) AGTR2EDNRACYP3A4
SCHEMBL30195091 0.83 ALOX5AP (0.47) AGTR2EDNRACYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4367110-A1 NEW SELECTIVE ANGIOTENSIN II COMPOUNDS Vicore Pharma AB (SE) 2024-05-15 EP claimed
CN-117916229-A Novel selective angiotensin II compounds 维科尔药物公司 2024-04-19 CN claimed
WO-2023281271-A1 NEW SELECTIVE ANGIOTENSIN II COMPOUNDS VICORE PHARMA AB (SE) 2023-01-12 WO claimed
US-12441718-B2 Selective angiotensin II compounds VICORE PHARMA AB (SE) 2025-10-14 US disclosed
US-20250101010-A1 SELECTIVE ANGIOTENSIN II COMPOUNDS VICORE PHARMA AB (SE) 2025-03-27 US disclosed
CN-117916229-A Novel selective angiotensin II compounds 维科尔药物公司 2024-04-19 CN disclosed
WO-2023281271-A1 NEW SELECTIVE ANGIOTENSIN II COMPOUNDS VICORE PHARMA AB (SE) 2023-01-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250101010-A1 SELECTIVE ANGIOTENSIN II COMPOUNDS AGTR1, AGTR2, REN PIK3CA 3997/4885AGTR2 2/4885EDNRA 34/4885
US-12441718-B2 Selective angiotensin II compounds AGTR1, AGTR2, REN PIK3CA 3997/4885AGTR2 2/4885EDNRA 34/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.