Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.36 |
| ▸ | FFAR3 | O14843 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CTSD | P07339 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4138857 | 0.83 | ALDH1A1 (0.41) | ALDH1A1CES2CES1HDAC3HDAC1 | |
| SCHEMBL6363285 | 0.83 | FFAR4 (0.48) | ALDH1A1CES2CES1LMNA | |
| SCHEMBL11444526 | 0.83 | FFAR4 (0.48) | ALDH1A1CES2CES1LMNA | |
| SCHEMBL5807529 | 0.83 | FFAR4 (0.48) | ALDH1A1CES2CES1LMNA | |
| SCHEMBL5806908 | 0.83 | FFAR4 (0.48) | ALDH1A1CES2CES1LMNA | |
| SCHEMBL5812121 | 0.83 | FFAR4 (0.48) | ALDH1A1CES2CES1LMNA | |
| Hydrochloric Acid SCHEMBL27323795 | 0.81 | ALDH1A1 (0.39) | ALDH1A1CES2CES1HDAC3HDAC1 | |
| SCHEMBL18673576 | 0.79 | ALDH1A1 (0.38) | ALDH1A1CES2CES1HDAC3HDAC1 | |
| SCHEMBL28639265 | 0.78 | CES2 (0.39) | ALDH1A1CES2CES1HDAC3HDAC1 | |
| SCHEMBL25874859 | 0.77 | ALDH1A1 (0.37) | ALDH1A1CES2CES1HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100216787-A1 | THIAZOLE DERIVATIVE | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2010-08-26 | — | — | US | disclosed |
| US-7678810-B2 | Thiazole derivative | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2010-03-16 | — | — | US | disclosed |
| US-20070154428-A1 | Thiazole derivative | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2007-07-05 | — | — | US | disclosed |
| EP-1721905-A1 | THIAZOLE DERIVATIVE | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2006-11-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216787-A1 | THIAZOLE DERIVATIVE | TGFBR1, TGFBR2, SMAD3 | ALDH1A1 294/4885CES2 3558/4885CES1 3615/4885 |
| US-20070154428-A1 | Thiazole derivative | TGFBR1, TGFBR2, SMAD3 | ALDH1A1 294/4885CES2 3558/4885CES1 3615/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.