Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PRNP | P04156 | 1/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3376941 | 0.93 | POLB (0.49) | POLBKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL3378020 | 0.86 | MEN1 (0.55) | POLBKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL3379160 | 0.86 | LMNA (0.49) | KMT2AMEN1ALDH1A1MAPTLMNA | |
| SCHEMBL2214557 | 0.83 | NAMPT (0.36) | KMT2AMEN1CYP1A2CYP3A4CYP19A1 | |
| SCHEMBL301861 | 0.79 | LMNA (0.49) | KMT2AMEN1ALDH1A1MAPTLMNA | |
| SCHEMBL303030 | 0.79 | GRM2 (0.54) | KMT2AMEN1ALDH1A1GAAMAPT | |
| SCHEMBL2210474 | 0.76 | MEN1 (0.42) | POLBKMT2AMEN1ALDH1A1GAA | |
| SCHEMBL301954 | 0.76 | LMNA (0.46) | KMT2AMEN1MAPTLMNAHTT | |
| SCHEMBL303525 | 0.76 | KMT2A (0.53) | POLBKMT2AMEN1MAPTPRNP | |
| SCHEMBL301862 | 0.76 | LMNA (0.51) | POLBKMT2AMEN1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2012500836-A | — | — | 2012-01-12 | — | — | JP | claimed |
| EP-2342177-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-07-13 | — | — | EP | claimed |
| WO-2010023448-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | XENTION LIMITED (GB) | 2010-03-04 | — | — | WO | claimed |