Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 13/20 | 0.54 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.41 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | LDHA | P00338 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1668131 | 0.88 | ELANE (0.55) | ELANE | |
| SCHEMBL12670691 | 0.85 | RORC (0.57) | ELANE | |
| SCHEMBL16517760 | 0.83 | PDE4A (0.56) | ELANEPDE4AKCNH2 | |
| SCHEMBL1667607 | 0.83 | ALDH1A1 (0.52) | ELANE | |
| SCHEMBL28825760 | 0.80 | ELANE (0.44) | ELANEPDE4AKCNH2 | |
| SCHEMBL8513964 | 0.79 | ELANE (0.51) | ELANELRRK2KDM4D | |
| SCHEMBL1670142 | 0.77 | ELANE (0.44) | ELANEPDE4AKCNH2 | |
| SCHEMBL12670692 | 0.76 | ELANE (0.54) | ELANE | |
| SCHEMBL12146949 | 0.76 | ELANE (0.57) | ELANELRRK2KDM4D | |
| SCHEMBL16464569 | 0.76 | ELANE (0.61) | ELANELRRK2KDM4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4387609-A2 | ARYL SULFONYL (HYDROXY) PIPERIDINES AS CCR6 INHIBITORS | ChemoCentryx, Inc. (US) | 2024-06-26 | — | — | EP | disclosed |
| WO-2023023532-A2 | ARYL SULFONYL (HYDROXY) PIPERIDINES AS CCR6 INHIBITORS | CHEMOCENTRYX, INC. (US) | 2023-02-23 | — | — | WO | disclosed |