Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 7/20 | 0.77 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.77 |
| ▸ | GABRA3 | P34903 | 7/20 | 0.77 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.77 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.61 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.58 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | GABRP | O00591 | 2/20 | 0.55 |
| ▸ | GABRD | O14764 | 2/20 | 0.55 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.55 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.55 |
| ▸ | GABRE | P78334 | 2/20 | 0.55 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.55 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.55 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.55 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.55 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23881487 | 1.00 | GABRA1 (0.77) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL31696096 | 0.87 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL638723 | 0.87 | GABRA1 (1.00) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL30202099 | 0.85 | CHRM1 (0.67) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL7323441 | 0.85 | LMNA (0.77) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL23881501 | 0.85 | CHRM1 (0.67) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL23881586 | 0.85 | GABRA1 (0.56) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL1421181 | 0.80 | KMT2A (0.82) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL30657216 | 0.80 | GABRA1 (0.69) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL18166494 | 0.79 | GABRA1 (0.77) | GABRA1GABRA5GABRA3GABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4139310-A1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | F. Hoffmann-La Roche AG (CH) | 2023-03-01 | — | — | EP | disclosed |
| EP-4126869-A1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAMS | F. Hoffmann-La Roche AG (CH) | 2023-02-08 | — | — | EP | disclosed |