Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.77 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.77 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.77 |
| ▸ | GABRA3 | P34903 | 7/20 | 0.77 |
| ▸ | GABRA2 | P47869 | 7/20 | 0.77 |
| ▸ | GABRB2 | P47870 | 6/20 | 0.77 |
| ▸ | GABRG2 | P18507 | 5/20 | 0.77 |
| ▸ | GABRB3 | P28472 | 5/20 | 0.77 |
| ▸ | GABRP | O00591 | 3/20 | 0.77 |
| ▸ | GABRD | O14764 | 3/20 | 0.77 |
| ▸ | GABRB1 | P18505 | 3/20 | 0.77 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.77 |
| ▸ | GABRE | P78334 | 3/20 | 0.77 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.77 |
| ▸ | GABRG1 | Q8N1C3 | 3/20 | 0.77 |
| ▸ | GABRG3 | Q99928 | 3/20 | 0.77 |
| ▸ | GABRQ | Q9UN88 | 3/20 | 0.77 |
| ▸ | CNR1 | P21554 | 1/20 | 0.67 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.67 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| N-Desalkyl-2-Oxoquazepam SCHEMBL30730010 | 0.87 | LMNA (1.00) | LMNAGABRA1GABRA5GABRA3GABRA2 | |
| N-Desalkyl-2-Oxoquazepam SCHEMBL30529978 | 0.87 | LMNA (1.00) | LMNAGABRA1GABRA5GABRA3GABRA2 | |
| N-Desalkyl-2-Oxoquazepam SCHEMBL5177297 | 0.87 | LMNA (1.00) | LMNAGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL7322840 | 0.85 | CHRM1 (0.77) | LMNAGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL30202071 | 0.85 | GABRA1 (0.77) | LMNAGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL23881586 | 0.85 | GABRA1 (0.56) | LMNAGABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL23881487 | 0.85 | GABRA1 (0.77) | LMNAGABRA1GABRA5GABRA3GABRA2 | |
| Nordazepam SCHEMBL31000330 | 0.80 | PDE4D (1.00) | LMNAGABRA1GABRA5GABRA3GABRA2 | |
| Nordazepam SCHEMBL29354494 | 0.80 | PDE4D (1.00) | LMNAGABRA1GABRA5GABRA3GABRA2 | |
| Nordazepam SCHEMBL8090999 | 0.80 | PDE4D (1.00) | LMNAGABRA1GABRA5GABRA3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3987052-A | SEDATIVES, TRANQUILIZERS, MUSCLE RELAXANTS | THE UPJOHN COMPANY (US) | 1976-10-19 | — | — | US | disclosed |
| US-3933816-A | 3-(Substituted aminomethyl)-7-substituted-3,5-dihydro-as-triazino[4,3-a][1,5]benzodiazepines | THE UPJOHN COMPANY (US) | 1976-01-20 | — | — | US | disclosed |
| US-3933794-A | CENTRAL NERVOUS SYSTEM DEPRESSANTS | THE UPJOHN COMPANY (US) | 1976-01-20 | — | — | US | disclosed |