Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 8/20 | 0.67 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.56 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.56 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.56 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.56 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.44 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.41 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23881501 | 1.00 | CHRM1 (0.67) | CHRM1GABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL10403256 | 0.90 | CHRM1 (0.53) | CHRM1GABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL7324283 | 0.87 | CHRM1 (0.73) | CHRM1GABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL11874459 | 0.87 | CHRM1 (0.58) | CHRM1GABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL30202071 | 0.85 | GABRA1 (0.77) | CHRM1GABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL23881487 | 0.85 | GABRA1 (0.77) | CHRM1GABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL23881527 | 0.85 | CHRM1 (0.77) | CHRM1GABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL7322840 | 0.85 | CHRM1 (0.77) | CHRM1GABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL2843067 | 0.80 | CHRM1 (1.00) | CHRM1GABRA1GABRA5GABRA3GABRA2 | |
| SCHEMBL7318315 | 0.79 | CHRM1 (0.74) | CHRM1GABRA1GABRA5GABRA3GABRA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4139310-A1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAM | F. Hoffmann-La Roche AG (CH) | 2023-03-01 | — | — | EP | disclosed |
| EP-4126869-A1 | BENZODIAZEPINE DERIVATIVES AS GABA A GAMMA1 PAMS | F. Hoffmann-La Roche AG (CH) | 2023-02-08 | — | — | EP | disclosed |