Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | SCN8A | Q9UQD0 | 7/20 | 0.41 |
| ▸ | SCN10A | Q9Y5Y9 | 7/20 | 0.41 |
| ▸ | RORB | Q92753 | 1/20 | 0.40 |
| ▸ | CFTR | P13569 | 1/20 | 0.40 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.40 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.40 |
| ▸ | GPR27 | Q9NS67 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9500830 | 0.82 | NPC1 (0.56) | NPC1RAB9AKMT2AALDH1A1HPGD | |
| SCHEMBL29276233 | 0.75 | RORB (0.43) | NPC1RAB9AKDM4EUSP2ALDH1A1 | |
| SCHEMBL2717104 | 0.74 | NPC1 (0.67) | NPC1RAB9AKMT2ABRAFHDAC1 | |
| SCHEMBL30214801 | 0.73 | KDM4E (0.43) | NPC1RAB9AKDM4EUSP2ALDH1A1 | |
| SCHEMBL422034 | 0.73 | ALDH1A1 (0.71) | NPC1RAB9AKDM4EUSP2ALDH1A1 | |
| SCHEMBL20384958 | 0.73 | KDM4E (0.58) | NPC1RAB9AKDM4EUSP2ALDH1A1 | |
| SCHEMBL24901813 | 0.72 | CFTR (0.67) | NPC1RAB9AKMT2AKDM4EUSP2 | |
| SCHEMBL1003490 | 0.72 | CFTR (0.54) | NPC1RAB9AKDM4EUSP2ALDH1A1 | |
| SCHEMBL426613 | 0.72 | KDM4E (0.53) | NPC1RAB9AKDM4EUSP2ALDH1A1 | |
| SCHEMBL697260 | 0.72 | NPC1 (0.50) | NPC1RAB9AKMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240262806-A1 | INHIBITORS OF NLRP3 | PCT THERAPEUTICS, INC. (US) | 2024-08-08 | — | — | US | disclosed |
| CN-118302417-A | NLRP3 inhibitors | PTC医疗公司 | 2024-07-05 | — | — | CN | disclosed |
| EP-4392414-A1 | INHIBITORS OF NLRP3 | PTC Therapeutics, Inc. (US) | 2024-07-03 | — | — | EP | disclosed |
| WO-2023028534-A1 | INHIBITORS OF NLRP3 | PTC THERAPEUTICS, INC. (US) | 2023-03-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240262806-A1 | INHIBITORS OF NLRP3 | NLRP3, NOD1, NLRP1 | NPC1 122/4885RAB9A 2196/4885KMT2A 3990/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.