Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 6/20 | 0.69 |
| ▸ | MMP2 | P08253 | 6/20 | 0.69 |
| ▸ | MMP9 | P14780 | 6/20 | 0.69 |
| ▸ | EGFR | P00533 | 6/20 | 0.69 |
| ▸ | MAOA | P21397 | 1/20 | 0.69 |
| ▸ | MAOB | P27338 | 1/20 | 0.69 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.66 |
| ▸ | RAB9A | P51151 | 7/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.64 |
| ▸ | NPC1 | O15118 | 5/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.64 |
| ▸ | MAPT | P10636 | 4/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.64 |
| ▸ | MEN1 | O00255 | 8/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.64 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15306486 | 1.00 | MMP1 (0.69) | MMP1MMP2MMP9EGFRMAOA | |
| 4-Nitro-Cinnamanilide SCHEMBL3021597 | 0.94 | MAPT (0.72) | MMP1MMP2MMP9EGFRMAOA | |
| 4-Nitro-(4'-Nitro)Cinnamanilide SCHEMBL5315660 | 0.92 | KMT2A (0.70) | MMP1MMP2MMP9EGFRMAOA | |
| SCHEMBL11590995 | 0.86 | EGFR (0.92) | MMP1MMP2MMP9EGFRMAOA | |
| SCHEMBL23547197 | 0.85 | TRPV1 (0.73) | MMP1MMP2MMP9EGFRMAOA | |
| SCHEMBL6754380 | 0.85 | TRPV1 (0.73) | MMP1MMP2MMP9EGFRMAOA | |
| SCHEMBL6754378 | 0.85 | TRPV1 (0.73) | MMP1MMP2MMP9EGFRMAOA | |
| SCHEMBL13675878 | 0.82 | TRPV1 (0.67) | RAB9ASMN1; SMN2NPC1ALDH1A1MAPT | |
| N-Phenylcinnamamide SCHEMBL3667414 | 0.82 | MMP1 (1.00) | MMP1MMP2MMP9EGFRMAOA | |
| N-Phenylcinnamamide SCHEMBL4205896 | 0.82 | MMP1 (1.00) | MMP1MMP2MMP9EGFRMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105017254-B | 4‑（4‑（（6 base of 9H purine）Sulphur）Phenyl）2 amine derivative of thiazolyl and its production and use | 四川大学 | 2017-04-05 | — | — | CN | disclosed |
| US-9162991-B2 | Cinnamoyl inhibitors of transglutaminase | UNIVERSITY OF OTTAWA (CA) | 2015-10-20 | — | — | US | disclosed |
| US-20140024837-A1 | CINNAMOYL INHIBITORS OF TRANSGLUTAMINASE | UNIVERSITE DE MONTREAL (CA) | 2014-01-23 | — | — | US | disclosed |
| US-8614233-B2 | Cinnamoyl inhibitors of transglutaminase | UNIVERSITE DE MONTREAL (CA) | 2013-12-24 | — | — | US | disclosed |
| US-20100204280-A1 | CINNAMOYL INHIBITORS OF TRANSGLUTAMINASE | UNIVERSITE DE MONTREAL (CA) | 2010-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204280-A1 | CINNAMOYL INHIBITORS OF TRANSGLUTAMINASE | TGM2, TGM3, TGM1 | MMP1 223/4885MMP2 43/4885MMP9 208/4885 |
| US-20140024837-A1 | CINNAMOYL INHIBITORS OF TRANSGLUTAMINASE | TGM2, TGM3, TFPI | MMP1 119/4885MMP2 32/4885MMP9 178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.