Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.44 |
| ▸ | PYCR1 | P32322 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 1/20 | 0.39 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.39 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24046693 | 1.00 | SIGMAR1 (0.44) | SIGMAR1PYCR1ATMCYP1A2MEN1 | |
| SCHEMBL25695746 | 0.83 | SIGMAR1 (0.51) | SIGMAR1ATMCYP1A2MEN1ALDH1A1 | |
| SCHEMBL30219766 | 0.76 | CYP1A2 (0.46) | SIGMAR1CYP1A2MEN1CYP2C19KMT2A | |
| SCHEMBL24046370 | 0.76 | CYP1A2 (0.46) | SIGMAR1CYP1A2MEN1CYP2C19KMT2A | |
| SCHEMBL8790689 | 0.73 | KDM4E (0.67) | SIGMAR1CYP1A2MEN1ALDH1A1KMT2A | |
| SCHEMBL30219772 | 0.71 | TSHR (0.40) | SIGMAR1CYP1A2MEN1ALDH1A1MAPT | |
| SCHEMBL24046632 | 0.71 | TSHR (0.40) | SIGMAR1CYP1A2MEN1ALDH1A1MAPT | |
| SCHEMBL24046372 | 0.70 | ADRB2 (0.38) | DAOCYP3A4CYP2D6 | |
| SCHEMBL30219759 | 0.70 | ADRB2 (0.38) | DAOCYP3A4CYP2D6 | |
| SCHEMBL374305 | 0.70 | ALDH1A1 (0.49) | SIGMAR1ATMMEN1ALDH1A1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4153175-A1 | PIPERIDINE-2,6-DIONES AS SMALL MOLECULE DEGRADERS OF HELIOS AND METHODS OF USE | Dana-Farber Cancer Institute, Inc. (US) | 2023-03-29 | — | — | EP | disclosed |