Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 5/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 5/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 2/20 | 0.36 |
| ▸ | TDP2 | O95551 | 2/20 | 0.36 |
| ▸ | TIPARP | Q7Z3E1 | 2/20 | 0.36 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | KDM4B | O94953 | 1/20 | 0.34 |
| ▸ | KDM5C | P41229 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23975908 | 1.00 | CHRNB2 (0.42) | CHRNB2CHRNA4SIGMAR1PDE3BPDE3A | |
| SCHEMBL17376995 | 0.92 | CHRNB2 (0.42) | CHRNB2CHRNA4SIGMAR1PDE3BPDE3A | |
| SCHEMBL89023 | 0.74 | ALOX15 (0.56) | CYP1A2TDP2 | |
| SCHEMBL7343370 | 0.74 | CYP1A2 (0.50) | CHRNB2CHRNA4SIGMAR1PDE3BPDE3A | |
| SCHEMBL8419080 | 0.73 | SIGMAR1 (0.56) | CHRNB2CHRNA4SIGMAR1CYP1A2 | |
| SCHEMBL29526300 | 0.72 | PDE3B (0.54) | PDE3BPDE3ACYP11B1CYP11B2CYP1A2 | |
| SCHEMBL658301 | 0.72 | PDE3B (0.59) | PDE3BPDE3ACYP11B1CYP11B2CYP1A2 | |
| SCHEMBL477609 | 0.72 | PDE3B (0.54) | PDE3BPDE3ACYP11B1CYP11B2CYP1A2 | |
| SCHEMBL19152529 | 0.72 | PDE3B (0.34) | PDE3BPDE3ACYP11B1CYP11B2CYP1A2 | |
| SCHEMBL1118591 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4142732-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | Global Blood Therapeutics, Inc. (US) | 2023-03-08 | — | — | EP | disclosed |
| EP-4143178-A1 | CYCLOALKYL PYRIMIDINES AS FERROPORTIN INHIBITORS | Global Blood Therapeutics, Inc. (US) | 2023-03-08 | — | — | EP | disclosed |