Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.55 |
| ▸ | BCHE | P06276 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 2/20 | 0.50 |
| ▸ | IGF1R | P08069 | 1/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
| ▸ | SRC | P12931 | 1/20 | 0.50 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.50 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.50 |
| ▸ | JAK1 | P23458 | 1/20 | 0.50 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | TYK2 | P29597 | 1/20 | 0.50 |
| ▸ | FLT4 | P35916 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.50 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.50 |
| ▸ | GSK3B | P49841 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23975678 | 1.00 | ACHE (0.55) | ACHEBCHECYP1A2CYP3A4ALOX15 | |
| SCHEMBL30225282 | 0.82 | HIF1A (0.54) | ACHEBCHECYP1A2CYP3A4ALOX15 | |
| SCHEMBL23975681 | 0.82 | HIF1A (0.54) | ACHEBCHECYP1A2CYP3A4ALOX15 | |
| SCHEMBL16838561 | 0.81 | PDE5A (0.55) | ACHEIGF1RKDM4EMEN1KMT2A | |
| SCHEMBL2588501 | 0.79 | VCP (0.56) | ACHEBCHEKDM4EMEN1KMT2A | |
| SCHEMBL17571943 | 0.77 | CCNA2 (0.45) | ACHEBCHECYP1A2CYP3A4IGF1R | |
| SCHEMBL23976163 | 0.76 | TDP1 (0.47) | CYP1A2NPC1RAB9AKMT2AHPGD | |
| SCHEMBL30225281 | 0.76 | TDP1 (0.47) | CYP1A2NPC1RAB9AKMT2AHPGD | |
| SCHEMBL17926565 | 0.74 | KMT2A (0.57) | CYP1A2CYP3A4LMNAKDM4ENPC1 | |
| SCHEMBL18303570 | 0.74 | LMNA (0.42) | LMNAMEN1KMT2AMAOBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4143178-A1 | CYCLOALKYL PYRIMIDINES AS FERROPORTIN INHIBITORS | Global Blood Therapeutics, Inc. (US) | 2023-03-08 | — | — | EP | disclosed |
| EP-4142732-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | Global Blood Therapeutics, Inc. (US) | 2023-03-08 | — | — | EP | disclosed |