Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.54 |
| ▸ | BCHE | P06276 | 2/20 | 0.53 |
| ▸ | ACHE | P22303 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | USP1 | O94782 | 2/20 | 0.46 |
| ▸ | WDR48 | Q8TAF3 | 2/20 | 0.46 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | PDE5A | O76074 | 3/20 | 0.45 |
| ▸ | CFTR | P13569 | 2/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23975681 | 1.00 | HIF1A (0.54) | HIF1ABCHEACHEALOX15CYP1A2 | |
| SCHEMBL30225331 | 0.82 | ACHE (0.55) | BCHEACHEALOX15CYP1A2CYP3A4 | |
| SCHEMBL23975678 | 0.82 | ACHE (0.55) | BCHEACHEALOX15CYP1A2CYP3A4 | |
| SCHEMBL23976252 | 0.81 | PDE4B (0.47) | HIF1ANPC1KDM4EUSP1WDR48 | |
| SCHEMBL30225366 | 0.81 | PDE4B (0.47) | HIF1ANPC1KDM4EUSP1WDR48 | |
| SCHEMBL20665835 | 0.81 | METAP2 (0.53) | HIF1AALOX15LMNAKDM4ERAB9A | |
| SCHEMBL26225716 | 0.80 | SMN1; SMN2 (0.46) | HIF1ABCHEACHEALOX15CYP1A2 | |
| SCHEMBL23975633 | 0.79 | PDE4B (0.52) | HIF1ALMNAKDM4EKMT2AGFER | |
| SCHEMBL30118572 | 0.77 | NPC1 (0.44) | HIF1ACYP1A2NPC1RAB9AKMT2A | |
| SCHEMBL23976244 | 0.77 | NPC1 (0.44) | HIF1ACYP1A2NPC1RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4142732-A1 | METHODS OF USE FOR PYRIMIDINES AS FERROPORTIN INHIBITORS | Global Blood Therapeutics, Inc. (US) | 2023-03-08 | — | — | EP | disclosed |
| EP-4143178-A1 | CYCLOALKYL PYRIMIDINES AS FERROPORTIN INHIBITORS | Global Blood Therapeutics, Inc. (US) | 2023-03-08 | — | — | EP | disclosed |