Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 3/20 | 0.41 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.41 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.41 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LDHA | P00338 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL3267690 | 1.00 | CA4 (0.41) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL9019048 | 1.00 | CA4 (0.41) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL599169 | 1.00 | CA4 (0.41) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL699842 | 1.00 | CA4 (0.41) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL5472175 | 1.00 | CA4 (0.41) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL5478239 | 1.00 | CA4 (0.41) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL700064 | 1.00 | CA4 (0.41) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL1933545 | 1.00 | CA4 (0.41) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL10433486 | 0.97 | CA4 (0.39) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL2025189 | 0.96 | CA4 (0.44) | CA4GLRA1SLC6A9OR51E2CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 47 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1521568-A1 | NON-IRRITATING ANTIPERSPIRANT COMPOSITIONS CONTAINING ACIDIC ANTIPERSPIRANT ACTIVE | THE PROCTER & GAMBLE COMPANY (US) | 2005-04-13 | — | — | EP | claimed |
| US-6835373-B2 | A particulate antiperspirant active having a metal to chloride molar ratio of <= to about 1.3, a volatile solvent, a low surface tension nonvolatile solvent and a suspending agent | THE PROCTER & GAMBLE COMPANY | 2004-12-28 | — | — | US | claimed |
| WO-2004006877-A1 | NON-IRRITATING ANTIPERSPIRANT COMPOSITIONS CONTAINING ACIDIC ANTIPERSPIRANT ACTIVE | THE PROCTER & GAMBLE COMPANY (US) | 2004-01-22 | — | — | WO | claimed |
| US-20040009133-A1 | Non-irritating antiperspirant compositions containing acidic antiperspirant active | THE PROCTER & GAMBLE COMPANY | 2004-01-15 | — | — | US | claimed |
| US-4774079-A | BUFFERS, ESPECIALLY GLYCINE, ACIDITY | BRISTOL-MYERS COMPANY (US) | 1988-09-27 | — | — | US | claimed |
| CN-118176284-A | Sanitary composition for reducing odor | 联合利华知识产权控股有限公司 | 2024-06-11 | — | — | CN | disclosed |
| US-20200121566-A1 | Methods of Making Solid Stick Antiperspirant Compositions | PROCTER & GAMBLE (US) | 2020-04-23 | — | — | US | disclosed |
| US-10576308-B2 | Antiperspirant products | THE PROCTER & GAMBLE COMPANY (US) | 2020-03-03 | — | — | US | disclosed |
| EP-2900203-B1 | METHODS OF MAKING SOLID STICK ANTIPERSPIRANT COMPOSITIONS | PROCTER & GAMBLE (US) | 2018-09-12 | — | — | EP | disclosed |
| EP-2900199-B1 | SOLID STICK ANTIPERSPIRANT COMPOSITIONS | PROCTER & GAMBLE (US) | 2018-09-05 | — | — | EP | disclosed |
| US-10016343-B2 | Solid stick antiperspirant compositions | THE PROCTER & GAMBLE COMPANY (US) | 2018-07-10 | — | — | US | disclosed |
| US-9795205-B2 | Dispensing package | THE PROCTER & GAMBLE COMPANY (US) | 2017-10-24 | — | — | US | disclosed |
| WO-2004006877-A1 | NON-IRRITATING ANTIPERSPIRANT COMPOSITIONS CONTAINING ACIDIC ANTIPERSPIRANT ACTIVE | THE PROCTER & GAMBLE COMPANY (US) | 2004-01-22 | — | — | WO | disclosed |
| US-20040009133-A1 | Non-irritating antiperspirant compositions containing acidic antiperspirant active | THE PROCTER & GAMBLE COMPANY | 2004-01-15 | — | — | US | disclosed |
| EP-0512770-B1 | Clear gelled cosmetic compositions and process for production | BRISTOL MYERS SQUIBB CO (US) | 1996-10-02 | — | — | EP | disclosed |
| US-5376363-A | Clear gelled antiperspirant stick composition | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-12-27 | — | — | US | disclosed |
| EP-0512770-A1 | Clear gelled cosmetic compositions and process for production | Bristol-Myers Squibb Company (US) | 1992-11-11 | — | — | EP | disclosed |
| US-4937069-A | FOR STABLE NONSTAINING STICKS | BRISTOL-MYERS SQUIBB COMPANY (US) | 1990-06-26 | — | — | US | disclosed |
| US-4777035-A | SUSPENSION OF HYDROPHOBIC SILICA IN ANHYDROUS OIL | BRISTOL-MYERS COMPANY (US) | 1988-10-11 | — | — | US | disclosed |
| US-4774079-A | BUFFERS, ESPECIALLY GLYCINE, ACIDITY | BRISTOL-MYERS COMPANY (US) | 1988-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040009133-A1 | Non-irritating antiperspirant compositions containing acidic antiperspirant active | SIGMAR1, PTPN6, PTPN14 | CA4 877/4885GLRA1 767/4885SLC6A9 964/4885 |
| US-10016343-B2 | Solid stick antiperspirant compositions | SUPT16H, SSRP1, U2SURP | CA4 3313/4885GLRA1 3241/4885SLC6A9 1706/4885 |
| US-10576308-B2 | Antiperspirant products | PPM1G, PSTPIP2, ATP6AP1 | CA4 1251/4885GLRA1 1115/4885SLC6A9 1459/4885 |
| US-20200121566-A1 | Methods of Making Solid Stick Antiperspirant Compositions | U2SURP, SUPT16H, RNGTT | CA4 3053/4885GLRA1 3511/4885SLC6A9 1549/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.