Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 3/20 | 0.41 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.41 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.41 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.37 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | LDHA | P00338 | 1/20 | 0.32 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Glycine SCHEMBL3267690 | 1.00 | CA4 (0.41) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL9019048 | 1.00 | CA4 (0.41) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL599169 | 1.00 | CA4 (0.41) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL699842 | 1.00 | CA4 (0.41) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL5472175 | 1.00 | CA4 (0.41) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL5478239 | 1.00 | CA4 (0.41) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL3028174 | 1.00 | CA4 (0.41) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL1933545 | 1.00 | CA4 (0.41) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL10433486 | 0.97 | CA4 (0.39) | CA4GLRA1SLC6A9OR51E2CASP1 | |
| Glycine SCHEMBL2025189 | 0.96 | CA4 (0.44) | CA4GLRA1SLC6A9OR51E2CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8349339-B2 | Antiperspirant or deodorant compositions | CONOPCO INC. (US) | 2013-01-08 | — | — | US | claimed |
| US-20060134037-A1 | Antiperspirant or deodorant compositions | CONOPCO INC, D/B/A UNILEVER | 2006-06-22 | — | — | US | claimed |
| US-9981149-B2 | Highly active antiperspirant with improved skin tolerability | HENKEL AG & CO. KGAA (DE) | 2018-05-29 | — | — | US | disclosed |
| US-20170348551-A1 | HIGHLY ACTIVE ANTIPERSPIRANT WITH IMPROVED SKIN TOLERABILITY | HENKEL AG & CO. KGAA (DE) | 2017-12-07 | — | — | US | disclosed |
| US-9549883-B2 | Textile friendly nonaerosol-antiperspirants with methansulfonic | HENKEL AG & CO. KGAA (DE) | 2017-01-24 | — | — | US | disclosed |
| US-9186304-B2 | Peg-free antiperspirant oil-in-water emulsions having improved feel | HENKEL AG & CO. KGAA (DE) | 2015-11-17 | — | — | US | disclosed |
| US-9095520-B2 | Textile friendly non-aerosol antiperspirants with a hydroxy acid | HENKEL AG & CO. KGAA (DE) | 2015-08-04 | — | — | US | disclosed |
| US-20150086499-A1 | THICKENED ANTIPERSPIRANT ROLL-ONS HAVING AN IMPROVED RESIDUE BEHAVIOR | HENKEL AG & CO. KGAA (DE) | 2015-03-26 | — | — | US | disclosed |
| US-20140301963-A1 | PEG-FREE ANTIPERSPIRANT OIL-IN-WATER EMULSIONS HAVING IMPROVED FEEL | HENKEL AG & CO. KGAA (DE) | 2014-10-09 | — | — | US | disclosed |
| US-20140173833-A1 | TEXTILE FRIENDLY NONAEROSOL-ANTIPERSPIRANTS WITH METHANSULFONIC | HENKEL AG & CO. KGAA (DE) | 2014-06-26 | — | — | US | disclosed |
| US-20140178321-A1 | TEXTILE FRIENDLY NON-AEROSOL ANTIPERSPIRANTS WITH A HYDROXY ACID | HENKEL AG & CO. KGAA (DE) | 2014-06-26 | — | — | US | disclosed |
| US-20100150856-A1 | STABILIZED AQUEOUS ALUMINUM ZIRCONIUM SOLUTIONS | SOMERVILLE TECHNOLOGY GROUP, INC. D/B/A SUMMIT RESEARCH LABS (US) | 2010-06-17 | — | — | US | disclosed |
| US-7731943-B2 | Stabilized aqueous aluminum zirconium solutions | SUMMIT RESEARCH LABS, INC. (US) | 2010-06-08 | — | — | US | disclosed |
| US-20090047226-A1 | Quick-drying cosmetic emulsions for roll-on application | HENKEL AG & C. KGAA (DE) | 2009-02-19 | — | — | US | disclosed |
| US-7294330-B2 | prevent decomposition of steroid ester; inhibit odors | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2007-11-13 | — | — | US | disclosed |
| US-20070253922-A1 | ANHYDROUS ANTIPERSPIRANT/DEODORANT STICK COMPOSITIONS | KAO CORPORATION (JP) | 2007-11-01 | — | — | US | disclosed |
| US-20060008435-A1 | Stabilized aqueous aluminum zirconium solutions | SOMERVILLE TECHNOLOGY GROUP, INC. D/B/A SUMMIT RESEARCH LABS (US) | 2006-01-12 | — | — | US | disclosed |
| WO-2005117812-A1 | STABILIZED AQUEOUS ALUMINUM ZIRCONIUM SOLUTIONS | SOMERVILLE TECHNOLOGY GROUP, INC. (US) | 2005-12-15 | — | — | WO | disclosed |
| US-20040234466-A1 | Beta-glucuronidase inhibitors for use in deodorants and antiperspirants | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (HENKEL KGAA) (DE) | 2004-11-25 | — | — | US | disclosed |
| US-20040170670-A1 | Cosmetic sponges | REGENESIS LLC | 2004-09-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140301963-A1 | PEG-FREE ANTIPERSPIRANT OIL-IN-WATER EMULSIONS HAVING IMPROVED FEEL | GGCT, GLUL, PPARG | CA4 2898/4885GLRA1 123/4885SLC6A9 720/4885 |
| US-20040234466-A1 | Beta-glucuronidase inhibitors for use in deodorants and antiperspirants | GUSB, PON1, IDUA | CA4 437/4885GLRA1 912/4885SLC6A9 1083/4885 |
| US-20090047226-A1 | Quick-drying cosmetic emulsions for roll-on application | CUTA, UGCG, MGLL | CA4 4633/4885GLRA1 2676/4885SLC6A9 3777/4885 |
| US-20140178321-A1 | TEXTILE FRIENDLY NON-AEROSOL ANTIPERSPIRANTS WITH A HYDROXY ACID | HRH1, NCEH1, HCAR1 | CA4 2501/4885GLRA1 841/4885SLC6A9 3484/4885 |
| US-20140173833-A1 | TEXTILE FRIENDLY NONAEROSOL-ANTIPERSPIRANTS WITH METHANSULFONIC | TST, MPST, CUTA | CA4 3664/4885GLRA1 3049/4885SLC6A9 1232/4885 |
| US-20060134037-A1 | Antiperspirant or deodorant compositions | DECR1, ADH1A, GDI2 | CA4 3533/4885GLRA1 1073/4885SLC6A9 1243/4885 |
| US-20040170670-A1 | Cosmetic sponges | CUTA, SUCLG1, AQP3 | CA4 2857/4885GLRA1 4103/4885SLC6A9 3737/4885 |
| US-20070253922-A1 | ANHYDROUS ANTIPERSPIRANT/DEODORANT STICK COMPOSITIONS | DRD4, DRD1, DRD2 | CA4 1434/4885GLRA1 2885/4885SLC6A9 1357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.