Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | NAAA | Q02083 | 1/20 | 0.45 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.45 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.45 |
| ▸ | ALDH1B1 | P30837 | 1/20 | 0.45 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.45 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30228338 | 0.83 | KCNA3 (0.50) | SMN1; SMN2ALDH1A1KCNA3GAAHPGD | |
| SCHEMBL30227927 | 0.82 | HSD17B10 (0.42) | NPC1SMN1; SMN2ALDH1A1KCNA3TP53 | |
| SCHEMBL30228133 | 0.82 | KCNA3 (0.42) | NPC1TDP1SMN1; SMN2ALDH1A1KCNA3 | |
| SCHEMBL30228280 | 0.81 | CHRM2 (0.51) | NPC1TDP1SMN1; SMN2ALDH1A1KCNA3 | |
| SCHEMBL30228272 | 0.81 | CHRM2 (0.51) | NPC1TDP1SMN1; SMN2ALDH1A1KCNA3 | |
| SCHEMBL30228194 | 0.81 | KCNA3 (0.48) | MAPTALDH1A1KCNA3GAAHPGD | |
| SCHEMBL30228032 | 0.80 | PLA2G7 (0.62) | NPC1MAPTSMN1; SMN2ALDH1A1KCNA3 | |
| SCHEMBL30227924 | 0.79 | KCNA3 (0.46) | NPC1MAPTSMN1; SMN2ALDH1A1KCNA3 | |
| SCHEMBL31710481 | 0.76 | KCNA3 (0.52) | TDP1SMN1; SMN2ALDH1A1ALDH2KCNA3 | |
| SCHEMBL30228381 | 0.75 | KCNA3 (0.56) | NPC1TDP1SMN1; SMN2ALDH1A1ALDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023034346-A1 | CHROMEN-2-ONE MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |