Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 3/20 | 0.45 |
| ▸ | CA9 | Q16790 | 3/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.45 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.45 |
| ▸ | MAOA | P21397 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.45 |
| ▸ | SORD | Q00796 | 1/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | LCK | P06239 | 2/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | GRB2 | P62993 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30228338 | 0.88 | KCNA3 (0.50) | KCNA3ALDH1A1HPGDSMN1; SMN2CA12 | |
| SCHEMBL30228381 | 0.84 | KCNA3 (0.56) | KCNA3RAB9AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL30227976 | 0.83 | KCNA3 (0.48) | KCNA3RAB9AALDH1A1HPGDSMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL30228355 | 0.83 | KCNA3 (0.55) | KCNA3RAB9AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL30767880 | 0.83 | CA9 (0.59) | RAB9AALDH1A1HPGDSMN1; SMN2CA12 | |
| SCHEMBL3250182 | 0.83 | CA9 (0.59) | RAB9AALDH1A1HPGDSMN1; SMN2CA12 | |
| SCHEMBL30228517 | 0.82 | KCNA3 (0.54) | KCNA3RAB9AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL30228194 | 0.81 | KCNA3 (0.48) | KCNA3RAB9AALDH1A1HPGDCA12 | |
| SCHEMBL30228231 | 0.81 | KCNA3 (0.53) | KCNA3RAB9AALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL30227920 | 0.81 | KCNA3 (0.53) | KCNA3RAB9AALDH1A1HPGDCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250326732-A1 | CHROMEN-2-ONE MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2025-10-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250326732-A1 | CHROMEN-2-ONE MODULATORS OF POLRMT | POLRMT, TFAM, POLM | KCNA3 4258/4885RAB9A 4007/4885ALDH1A1 3178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.