Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 5/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.42 |
| ▸ | RECQL | P46063 | 3/20 | 0.42 |
| ▸ | CTDSP1 | Q9GZU7 | 2/20 | 0.42 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.42 |
| ▸ | APEX1 | P27695 | 1/20 | 0.42 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.42 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31711268 | 0.89 | ALDH1A1 (0.50) | KCNA3POLBKDM4ETDP1CTDSP1 | |
| SCHEMBL30228467 | 0.89 | ALDH1A1 (0.50) | KCNA3POLBKDM4ETDP1CTDSP1 | |
| SCHEMBL31710963 | 0.89 | ALDH1A1 (0.50) | KCNA3POLBKDM4ETDP1CTDSP1 | |
| SCHEMBL30228046 | 0.89 | ALDH1A1 (0.50) | KCNA3POLBKDM4ETDP1CTDSP1 | |
| SCHEMBL30228062 | 0.87 | ALDH1A1 (0.61) | POLBKDM4EHPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL30228407 | 0.84 | KCNA3 (0.48) | KCNA3KDM4ERECQLHPGDALDH1A1 | |
| SCHEMBL30227980 | 0.82 | NPC1 (0.45) | KCNA3TDP1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL30228280 | 0.80 | CHRM2 (0.51) | KCNA3TDP1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL30228272 | 0.80 | CHRM2 (0.51) | KCNA3TDP1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL30228032 | 0.79 | PLA2G7 (0.62) | KCNA3POLBRECQLHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023034346-A1 | CHROMEN-2-ONE MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |