Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.42 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 2/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.41 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.41 |
| ▸ | ERN1 | O75460 | 2/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31562706 | 0.89 | HDAC8 (0.50) | SMN1; SMN2MAPTALDH1A1L3MBTL1LMNA | |
| SCHEMBL13199092 | 0.88 | MAOB (0.50) | SMN1; SMN2MAPTALDH1A1L3MBTL1LMNA | |
| SCHEMBL21957648 | 0.80 | HDAC8 (0.54) | SMN1; SMN2MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL12581731 | 0.79 | SMN1; SMN2 (0.50) | SMN1; SMN2MAPTALDH1A1L3MBTL1LMNA | |
| SCHEMBL10469385 | 0.79 | RAB9A (0.49) | SMN1; SMN2MAPTL3MBTL1LMNAHPGD | |
| SCHEMBL3211263 | 0.79 | HDAC8 (0.51) | SMN1; SMN2MAPTALDH1A1LMNAHPGD | |
| SCHEMBL24913942 | 0.78 | NPC1 (0.48) | SMN1; SMN2MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL13404092 | 0.78 | NPC1 (0.48) | SMN1; SMN2MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL1745424 | 0.77 | MAOB (0.53) | SMN1; SMN2MAPTL3MBTL1NPC1RAB9A | |
| SCHEMBL3533022 | 0.77 | NPC1 (0.47) | SMN1; SMN2MAPTL3MBTL1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4395549-A1 | COMPOSITIONS AND METHODS FOR TARGETED DEGRADATION OF PROTEINS IN A PLANT CELL | Oerth Bio LLC (US) | 2024-07-10 | — | — | EP | disclosed |
| WO-2023034411-A1 | COMPOSITIONS AND METHODS FOR TARGETED DEGRADATION OF PROTEINS IN A PLANT CELL | OERTH BIO LLC (US) | 2023-03-09 | — | — | WO | disclosed |