Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.59 |
| ▸ | HPGD | P15428 | 10/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.53 |
| ▸ | AR | P10275 | 2/20 | 0.51 |
| ▸ | RECQL | P46063 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | IGLV6-57 | P01721 | 3/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30231379 | 1.00 | ALDH1A1 (0.59) | ALDH1A1HPGDKDM4EHTTHSD17B10 | |
| SCHEMBL30231486 | 1.00 | ALDH1A1 (0.59) | ALDH1A1HPGDKDM4EHTTHSD17B10 | |
| SCHEMBL30231415 | 0.91 | ALDH1A1 (0.54) | ALDH1A1HPGDKDM4EHTTHSD17B10 | |
| SCHEMBL30231699 | 0.91 | ALDH1A1 (0.54) | ALDH1A1HPGDKDM4EHTTHSD17B10 | |
| SCHEMBL30231414 | 0.91 | ALDH1A1 (0.54) | ALDH1A1HPGDKDM4EHTTHSD17B10 | |
| SCHEMBL30231271 | 0.91 | ALDH1A1 (0.54) | ALDH1A1HPGDKDM4EHTTHSD17B10 | |
| SCHEMBL30231519 | 0.91 | ALDH1A1 (0.60) | ALDH1A1HPGDKDM4EHTTHSD17B10 | |
| SCHEMBL30231666 | 0.91 | ALDH1A1 (0.60) | ALDH1A1HPGDKDM4EHTTHSD17B10 | |
| SCHEMBL30231326 | 0.91 | ALDH1A1 (0.60) | ALDH1A1HPGDKDM4EHTTHSD17B10 | |
| SCHEMBL30231874 | 0.90 | ALDH1A1 (0.49) | ALDH1A1HPGDKDM4EHTTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240368106-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2024-11-07 | — | — | US | disclosed |
| WO-2023034340-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |
| WO-2023034339-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | PRETZEL THERAPEUTICS, INC. (US) | 2023-03-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240368106-A1 | HYDROXY AND ALKOXY COUMARINS AS MODULATORS OF POLRMT | POLRMT, ACAT1, TFAM | ALDH1A1 909/4885HPGD 882/4885KDM4E 2584/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.