Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 6/20 | 1.00 |
| ▸ | CASP1 | P29466 | 2/20 | 1.00 |
| ▸ | CASP4 | P49662 | 2/20 | 1.00 |
| ▸ | CASP7 | P55210 | 2/20 | 1.00 |
| ▸ | CASP9 | P55211 | 2/20 | 1.00 |
| ▸ | CASP6 | P55212 | 2/20 | 1.00 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.65 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.65 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.56 |
| ▸ | PTPRC | P08575 | 3/20 | 0.53 |
| ▸ | S100A4 | P26447 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TTR | P02766 | 2/20 | 0.49 |
| ▸ | CES1 | P23141 | 2/20 | 0.49 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.48 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3594484 | 1.00 | CASP3 (1.00) | CASP3CASP1CASP4CASP7CASP9 | |
| SCHEMBL26621563 | 0.87 | CASP3 (0.77) | CASP3CASP1CASP4CASP7CASP9 | |
| SCHEMBL31419431 | 0.84 | CASP3 (0.72) | CASP3CASP1CASP4CASP7CASP9 | |
| Isatin SCHEMBL2543770 | 0.83 | CASP3 (0.70) | CASP3CASP1CASP4CASP7CASP9 | |
| SCHEMBL7094984 | 0.81 | CA1 (0.70) | CASP3CASP1CASP4CASP7CASP9 | |
| SCHEMBL28585158 | 0.80 | CASP1 (0.67) | CASP3CASP1CASP4CASP7CASP9 | |
| SCHEMBL3651922 | 0.80 | CASP3 (0.67) | CASP3CASP1CASP4CASP7CASP9 | |
| SCHEMBL28031452 | 0.80 | CASP3 (0.67) | CASP3CASP1CASP4CASP7CASP9 | |
| SCHEMBL23250129 | 0.80 | CASP3 (0.66) | CASP3CASP1CASP4CASP7CASP9 | |
| SCHEMBL21774731 | 0.80 | CASP1 (0.67) | CASP3CASP1CASP4CASP7CASP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119019369-A | Bifunctional molecules comprising an E3 ubiquitin ligase binding moiety linked to a BCL6 targeting moiety | 阿尔维纳斯运营股份有限公司 | 2024-11-26 | — | — | CN | disclosed |
| CN-115397821-B | Bifunctional molecules comprising an E3 ubiquitin ligase binding moiety linked to a BCL6 targeting moiety | 阿尔维纳斯运营股份有限公司 | 2024-09-03 | — | — | CN | disclosed |
| EP-4380919-A1 | CYANOPYRIDINE AND CYANOPYRIMIDINE BCL6 DEGRADERS | Dana-Farber Cancer Institute, Inc. (US) | 2024-06-12 | — | — | EP | disclosed |
| CN-117980290-A | Cyanopyridine and cyanopyrimidine BCL6 degrading agents | 达纳－法伯癌症研究所公司 | 2024-05-03 | — | — | CN | disclosed |
| WO-2023015164-A1 | CYANOPYRIDINE AND CYANOPYRIMIDINE BCL6 DEGRADERS | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2023-02-09 | — | — | WO | disclosed |