Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 6/20 | 1.00 |
| ▸ | CASP1 | P29466 | 2/20 | 1.00 |
| ▸ | CASP4 | P49662 | 2/20 | 1.00 |
| ▸ | CASP7 | P55210 | 2/20 | 1.00 |
| ▸ | CASP9 | P55211 | 2/20 | 1.00 |
| ▸ | CASP6 | P55212 | 2/20 | 1.00 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.65 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.65 |
| ▸ | CA1 | P00915 | 1/20 | 0.57 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.56 |
| ▸ | PTPRC | P08575 | 3/20 | 0.53 |
| ▸ | S100A4 | P26447 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TTR | P02766 | 2/20 | 0.49 |
| ▸ | CES1 | P23141 | 2/20 | 0.49 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.48 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30232255 | 1.00 | CASP3 (1.00) | CASP3CASP1CASP4CASP7CASP9 | |
| SCHEMBL26621563 | 0.87 | CASP3 (0.77) | CASP3CASP1CASP4CASP7CASP9 | |
| SCHEMBL31419431 | 0.84 | CASP3 (0.72) | CASP3CASP1CASP4CASP7CASP9 | |
| Isatin SCHEMBL2543770 | 0.83 | CASP3 (0.70) | CASP3CASP1CASP4CASP7CASP9 | |
| SCHEMBL7094984 | 0.81 | CA1 (0.70) | CASP3CASP1CASP4CASP7CASP9 | |
| SCHEMBL28585158 | 0.80 | CASP1 (0.67) | CASP3CASP1CASP4CASP7CASP9 | |
| SCHEMBL3651922 | 0.80 | CASP3 (0.67) | CASP3CASP1CASP4CASP7CASP9 | |
| SCHEMBL28031452 | 0.80 | CASP3 (0.67) | CASP3CASP1CASP4CASP7CASP9 | |
| SCHEMBL23250129 | 0.80 | CASP3 (0.66) | CASP3CASP1CASP4CASP7CASP9 | |
| SCHEMBL21774731 | 0.80 | CASP1 (0.67) | CASP3CASP1CASP4CASP7CASP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 71 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109384769-B | Synthetic method of R-configuration 3-substituted-3-hydroxy oxindole compound | 陕西师范大学 | 2020-12-22 | — | — | CN | claimed |
| CN-101503404-A | Preparation of 3-substituted-3-hydroxy-indole-2-ketone bis-heterocyclic derivative | UNIV EAST CHINA NORMAL (CN) | 2009-08-12 | — | — | CN | claimed |
| WO-2000038636-A1 | AGENT FOR DYING KERATIN FIBERS | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2000-07-06 | — | — | WO | claimed |
| US-12310975-B2 | Modulators of BCL6 proteolysis and associated methods of use | ARVINAS OPERATIONS, INC. (US) | 2025-05-27 | — | — | US | disclosed |
| US-20250074890-A1 | CYANOPYRIDINE AND CYANOPYRIMIDINE BCL6 DEGRADERS | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2025-03-06 | — | — | US | disclosed |
| EP-4380919-A1 | CYANOPYRIDINE AND CYANOPYRIMIDINE BCL6 DEGRADERS | Dana-Farber Cancer Institute, Inc. (US) | 2024-06-12 | — | — | EP | disclosed |
| CN-117980290-A | Cyanopyridine and cyanopyrimidine BCL6 degrading agents | 达纳－法伯癌症研究所公司 | 2024-05-03 | — | — | CN | disclosed |
| EP-3728232-B1 | NOVEL QUINOLONE COMPOUNDS AS INHIBITORS OF THE BCL6 BTB DOMAIN PROTEIN-PROTEIN INTERACTION AND/OR AS BCL6 DEGRADERS | ONTARIO INSTITUTE FOR CANCER RES OICR (CA) | 2023-08-30 | — | — | EP | disclosed |
| EP-3728232-B1 | NOVEL QUINOLONE COMPOUNDS AS INHIBITORS OF THE BCL6 BTB DOMAIN PROTEIN-PROTEIN INTERACTION AND/OR AS BCL6 DEGRADERS | ONTARIO INSTITUTE FOR CANCER RES OICR (CA) | 2023-08-30 | — | — | EP | disclosed |
| CN-112538083-B | Aromatic ring penta aromatic heterocyclic micromolecule organic compound targeting BCL6, derivative thereof and application thereof | 华东师范大学 | 2023-04-28 | — | — | CN | disclosed |
| CN-113735871-B | Preparation method and application of indole spiro dihydropyridine dicoumarol compound | 江苏大学 | 2023-04-11 | — | — | CN | disclosed |
| US-20060063791-A1 | (Spirocyclylamido)aminothiophene compounds | OSI PHARMACEUTICALS, INC. | 2006-03-23 | — | — | US | disclosed |
| WO-2005082900-A2 | OXAZOLIDINONE AMIDOXIMES AS ANTIBACTERIAL AGENTS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2005-09-09 | — | — | WO | disclosed |
| WO-2000038636-A1 | AGENT FOR DYING KERATIN FIBERS | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 2000-07-06 | — | — | WO | disclosed |
| EP-0432648-B1 | Isatine derivatives, their preparation and use | NEUROSEARCH AS (DK) | 1995-08-02 | — | — | EP | disclosed |
| US-5198461-A | Isatine derivatives, their preparation and use | NEUROSEARCH A/S (DK) | 1993-03-30 | — | — | US | disclosed |
| US-5192792-A | Isatine derivatives, and their method of use | WARNER-LAMBERT COMPANY (US) | 1993-03-09 | — | — | US | disclosed |
| US-5164404-A | HYDRAZONE DERIVATIVES AND THEIR USE | NEUROSEARCH A/S (DK) | 1992-11-17 | — | — | US | disclosed |
| EP-0503349-A1 | Hydrazone derivatives, their preparation and use | NEUROSEARCH A/S (DK) | 1992-09-16 | — | — | EP | disclosed |
| EP-0432648-A2 | Isatine derivatives, their preparation and use | NEUROSEARCH A/S (DK) | 1991-06-19 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12310975-B2 | Modulators of BCL6 proteolysis and associated methods of use | BCL6, BCL6B, BCL3 | CASP3 932/4885CASP1 837/4885CASP4 939/4885 |
| US-20250074890-A1 | CYANOPYRIDINE AND CYANOPYRIMIDINE BCL6 DEGRADERS | BCL6, BCL6B, BCOR | CASP3 834/4885CASP1 650/4885CASP4 521/4885 |
| US-20060063791-A1 | (Spirocyclylamido)aminothiophene compounds | KIT, BRDT, MALT1 | CASP3 986/4885CASP1 471/4885CASP4 1918/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.