Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 5/20 | 0.48 |
| ▸ | CDK2 | P24941 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | GALR2 | O43603 | 3/20 | 0.43 |
| ▸ | GALR1 | P47211 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23867526 | 1.00 | CCNE1 (0.48) | CCNE1CDK2LMNAMAPTMAOB | |
| SCHEMBL30165660 | 0.85 | CCNE1 (0.43) | CCNE1CDK2LMNAMAPTKDM4E | |
| SCHEMBL23867488 | 0.82 | LMNA (0.42) | CCNE1CDK2LMNAMAPTKDM4E | |
| SCHEMBL23859943 | 0.81 | HRH3 (0.53) | CCNE1CDK2LMNAMAPTHTR2C | |
| SCHEMBL30165658 | 0.81 | HRH3 (0.53) | CCNE1CDK2LMNAMAPTHTR2C | |
| SCHEMBL30234371 | 0.78 | ROCK1 (0.46) | CCNE1CDK2LMNAMAPTKDM4E | |
| SCHEMBL11506640 | 0.75 | GALR2 (0.66) | LMNAMAPTKDM4EGALR2GALR1 | |
| SCHEMBL31094236 | 0.74 | CCNE1 (0.47) | CCNE1CDK2LMNAMAPTKDM4E | |
| SCHEMBL23867469 | 0.74 | CCNE1 (0.45) | CCNE1CDK2LMNAMAPTKDM4E | |
| SCHEMBL23867651 | 0.74 | LMNA (0.53) | CCNE1CDK2LMNAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118338898-A | Small molecule inhibitors of oncogenic CHD1L with preclinical anti-colorectal cancer activity | 科罗拉多州立大学董事会（法人团体） | 2024-07-12 | — | — | CN | disclosed |
| WO-2023055763-A2 | SMALL MOLECULE INHIBITORS OF ONCOGENIC CHD1L WITH PRECLINICAL ACTIVITY AGAINST COLORECTRAL CANCER | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2023-04-06 | — | — | WO | disclosed |