Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.51 |
| ▸ | CCNE1 | P24864 | 5/20 | 0.50 |
| ▸ | CDK2 | P24941 | 5/20 | 0.50 |
| ▸ | GALR2 | O43603 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
| ▸ | TGM2 | P21980 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.46 |
| ▸ | JAK3 | P52333 | 1/20 | 0.46 |
| ▸ | GALR1 | P47211 | 1/20 | 0.46 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.45 |
| ▸ | CTSC | P53634 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23867649 | 0.80 | ALDH1A1 (0.52) | LMNAMAPTHSD17B10ALDH1A1KDM4E | |
| SCHEMBL30234817 | 0.80 | LMNA (0.52) | LMNAMAPTHSD17B10ALDH1A1KDM4E | |
| SCHEMBL31094226 | 0.80 | MAPT (0.44) | LMNAMAPTHSD17B10ALDH1A1KDM4E | |
| SCHEMBL23859940 | 0.78 | MAPT (0.62) | LMNAMAPTHSD17B10ALDH1A1KDM4E | |
| SCHEMBL11506640 | 0.78 | GALR2 (0.66) | LMNAMAPTKDM4EGALR2MAPK1 | |
| SCHEMBL23859942 | 0.77 | POLB (0.55) | LMNAMAPTHSD17B10ALDH1A1KDM4E | |
| SCHEMBL31094223 | 0.77 | CCNE1 (0.48) | LMNAMAPTHSD17B10ALDH1A1KDM4E | |
| SCHEMBL30234151 | 0.77 | IMPDH2 (0.46) | LMNAMAPTHSD17B10ALDH1A1KDM4E | |
| SCHEMBL31094238 | 0.76 | SLC2A1 (0.50) | LMNAMAPTHSD17B10ALDH1A1KDM4E | |
| SCHEMBL31094225 | 0.76 | CCNE1 (0.49) | LMNAMAPTHSD17B10ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021195279-A2 | SMALL MOLECULE INHIBITORS OF ONCOGENIC CHD1L WITH PRECLINICAL ACTIVITY AGAINST COLORECTAL CANCER | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE (US) | 2021-09-30 | — | — | WO | disclosed |