Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.46 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.46 |
| ▸ | SMARCA2 | P51531 | 5/20 | 0.43 |
| ▸ | SMARCA4 | P51532 | 4/20 | 0.43 |
| ▸ | GRM5 | P41594 | 2/20 | 0.40 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 2/20 | 0.37 |
| ▸ | CA9 | Q16790 | 2/20 | 0.37 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.37 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15114397 | 0.86 | TAS1R3 (0.44) | TAS1R3TAS1R1TAS1R2SMARCA2SMARCA4 | |
| SCHEMBL24198786 | 0.80 | TAS1R3 (0.42) | TAS1R3TAS1R1TAS1R2SMARCA2SMARCA4 | |
| SCHEMBL30237159 | 0.78 | FTO (0.62) | — | |
| SCHEMBL29272136 | 0.78 | FTO (0.62) | — | |
| Tert-Butanol SCHEMBL27878420 | 0.77 | KDM4C (0.52) | TAS1R3TAS1R1TAS1R2SMARCA2SMARCA4 | |
| SCHEMBL364320 | 0.76 | SMARCA2 (0.49) | TAS1R3TAS1R1TAS1R2SMARCA2SMARCA4 | |
| SCHEMBL29640105 | 0.76 | SMARCA2 (0.49) | TAS1R3TAS1R1TAS1R2SMARCA2SMARCA4 | |
| SCHEMBL24198795 | 0.75 | TAS1R3 (0.38) | TAS1R3TAS1R1TAS1R2SMARCA2SMARCA4 | |
| SCHEMBL27623752 | 0.75 | RECQL (0.47) | TAS1R3TAS1R1TAS1R2SMARCA2SMARCA4 | |
| SCHEMBL13701663 | 0.75 | TAS1R3 (0.51) | TAS1R3TAS1R1TAS1R2SMARCA2SMARCA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4399210-A1 | 6-AZA-QUINOLINE DERIVATIVES AND RELATED USES | Black Diamond Therapeutics, Inc. (US) | 2024-07-17 | — | — | EP | disclosed |
| CN-118159537-A | 6-Aza-quinoline derivatives and related uses | 黑钻治疗公司 | 2024-06-07 | — | — | CN | disclosed |
| WO-2023039505-A1 | 6-AZA-QUINOLINE DERIVATIVES AND RELATED USES | BLACK DIAMOND THERAPEUTICS, INC. (US) | 2023-03-16 | — | — | WO | disclosed |