Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.40 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.36 |
| ▸ | AKR1C1 | Q04828 | 2/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17202038 | 0.76 | L3MBTL1 (0.44) | MAP4K4MEN1KMT2ALMNAL3MBTL1 | |
| SCHEMBL23214268 | 0.76 | OPRM1 (0.42) | MEN1KMT2A | |
| SCHEMBL29844920 | 0.76 | OPRM1 (0.42) | MEN1KMT2A | |
| SCHEMBL31247665 | 0.73 | NAPRT (0.47) | NAPRTAKR1C1MAP4K4AKR1C3AKR1C2 | |
| SCHEMBL349552 | 0.73 | NAPRT (0.47) | NAPRTAKR1C1MAP4K4AKR1C3AKR1C2 | |
| SCHEMBL2143498 | 0.72 | KDM4E (0.44) | NAPRTAKR1C1CYP3A4LMNA | |
| SCHEMBL29886318 | 0.70 | MAP4K4 (0.46) | AKR1C1MAP4K4MEN1KMT2AL3MBTL1 | |
| SCHEMBL28590075 | 0.70 | MAP4K4 (0.46) | AKR1C1MAP4K4MEN1KMT2AL3MBTL1 | |
| SCHEMBL31759481 | 0.70 | NAPRT (0.33) | SIRT6NAPRTAKR1C1MAP4K4AKR1C3 | |
| SCHEMBL20778447 | 0.69 | AKR1C1 (0.36) | AKR1C1MAP4K4AKR1C3AKR1C2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110214135-B | Indanyl amino pyrazinyl cyclopropane carboxylic acid, pharmaceutical composition and application thereof | 勃林格殷格翰国际有限公司 | 2023-02-21 | — | — | CN | disclosed |