Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | SORT1 | Q99523 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TET3 | O43151 | 1/20 | 0.37 |
| ▸ | FBXL19 | Q6PCT2 | 1/20 | 0.37 |
| ▸ | CXXC5 | Q7LFL8 | 1/20 | 0.37 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.37 |
| ▸ | CXXC4 | Q9H2H0 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28590075 | 0.93 | MAP4K4 (0.46) | L3MBTL1PTK2OPRM1OPRL1MAP4K4 | |
| SCHEMBL29886318 | 0.93 | MAP4K4 (0.46) | L3MBTL1PTK2OPRM1OPRL1MAP4K4 | |
| Hydrochloric Acid SCHEMBL28600379 | 0.92 | MAP4K4 (0.45) | L3MBTL1PTK2OPRM1OPRL1MAP4K4 | |
| SCHEMBL16573736 | 0.80 | PTK2 (0.45) | L3MBTL1PTK2OPRM1OPRL1LMNA | |
| SCHEMBL17018563 | 0.80 | PTK2 (0.42) | L3MBTL1PTK2OPRM1OPRL1TDP1 | |
| SCHEMBL28600377 | 0.79 | L3MBTL1 (0.42) | L3MBTL1PTK2OPRM1OPRL1MAP4K4 | |
| SCHEMBL29886419 | 0.79 | L3MBTL1 (0.42) | L3MBTL1PTK2OPRM1OPRL1MAP4K4 | |
| SCHEMBL1759727 | 0.79 | APP (0.40) | OPRM1OPRL1 | |
| SCHEMBL5526276 | 0.79 | ALDH1A1 (0.47) | OPRM1OPRL1KMT2AMEN1NPSR1 | |
| SCHEMBL30239786 | 0.76 | SIRT6 (0.40) | L3MBTL1MAP4K4KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9409882-B2 | Pyridine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2016-08-09 | — | — | US | disclosed |
| US-9409882-B2 | Pyridine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2016-08-09 | — | — | US | disclosed |
| US-9409882-B2 | Pyridine derivatives | HOFFMANN-LA ROCHE INC. (US) | 2016-08-09 | — | — | US | disclosed |
| US-20150307472-A1 | NOVEL PYRIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2015-10-29 | — | — | US | disclosed |
| US-20150307472-A1 | NOVEL PYRIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2015-10-29 | — | — | US | disclosed |
| US-20150307472-A1 | NOVEL PYRIDINE DERIVATIVES | HOFFMANN-LA ROCHE INC. (US) | 2015-10-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150307472-A1 | NOVEL PYRIDINE DERIVATIVES | NDUFS6, ADORA1, COX6A1 | L3MBTL1 3977/4885PTK2 3802/4885OPRM1 410/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.