Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PGR | P06401 | 13/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | DPP4 | P27487 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | AR | P10275 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.42 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3037282 | 0.82 | PGR (0.51) | PGRDPP4HDAC8HDAC6KCNH2 | |
| SCHEMBL3025009 | 0.80 | DPP4 (0.50) | PGRDPP4HDAC8HDAC6AR | |
| SCHEMBL5031248 | 0.80 | PGR (0.44) | PGRDPP4HDAC8HDAC6AR | |
| SCHEMBL3825571 | 0.79 | PGR (0.49) | PGRDPP4HDAC8HDAC6AR | |
| SCHEMBL3825564 | 0.79 | PGR (0.49) | PGRDPP4HDAC8HDAC6AR | |
| SCHEMBL3029883 | 0.79 | PGR (0.53) | PGRDPP4HDAC8HDAC6AR | |
| SCHEMBL17948919 | 0.79 | CHEK1 (0.46) | PGRPOLBARKCNH2NR3C1 | |
| SCHEMBL13658415 | 0.77 | POLB (0.51) | POLBDPP4KCNH2 | |
| SCHEMBL4453837 | 0.77 | PGR (0.48) | PGRDPP4HDAC8HDAC6AR | |
| SCHEMBL3029493 | 0.77 | PGR (0.48) | PGRDPP4HDAC8HDAC6AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100216813-A1 | PYRROLIDINEANILINES | SMITHKLINE BEECHAM CORPORATION | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216813-A1 | PYRROLIDINEANILINES | PGF, ARG1, CYP19A1 | PGR 11/4885POLB 2676/4885DPP4 3862/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.