Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOD2 | Q9HC29 | 5/20 | 0.45 |
| ▸ | NOD1 | Q9Y239 | 5/20 | 0.45 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.38 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.38 |
| ▸ | F10 | P00742 | 2/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3023843 | 0.91 | NOD2 (0.45) | NOD2NOD1ADORA3LMNACYP1A2 | |
| SCHEMBL5623839 | 0.88 | NOD2 (0.52) | NOD2NOD1ADORA3NR1H2MEN1 | |
| SCHEMBL13173591 | 0.87 | NOD2 (0.46) | NOD2NOD1LMNACYP1A2MAOA | |
| SCHEMBL3033212 | 0.86 | NR1H2 (0.41) | NR1H2NR1H3AURKACDK2 | |
| SCHEMBL5065658 | 0.86 | NOD2 (0.47) | NOD2NOD1NR1H2MEN1KMT2A | |
| SCHEMBL31095788 | 0.86 | NOD2 (0.45) | NOD2NOD1LMNANR1H2MEN1 | |
| SCHEMBL24894603 | 0.84 | NOD2 (0.62) | NOD2NOD1NR1H2MEN1KMT2A | |
| SCHEMBL29827958 | 0.84 | NOD2 (0.62) | NOD2NOD1NR1H2MEN1KMT2A | |
| SCHEMBL3060429 | 0.83 | SCN9A (0.40) | NOD2NOD1ADORA3CYP1A2NR1H2 | |
| SCHEMBL3033204 | 0.82 | NOD2 (0.51) | NOD2NOD1LMNAMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8304419-B2 | Chemical compounds | GLAXOSMITHKLINE LLC (US) | 2012-11-06 | — | — | US | disclosed |
| US-20100216746-A1 | CHEMICAL COMPOUNDS | GLAXOSMITHKLINE LLC (US) | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216746-A1 | CHEMICAL COMPOUNDS | SAMHD1, POLRMT, NUDT1 | NOD2 4324/4885NOD1 3097/4885ADORA3 1357/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.