Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 4/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | MAP4K1 | Q92918 | 4/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 2/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30253230 | 0.81 | PIK3CD (0.47) | MTORCYP11B2MAP4K1NTRK1PIK3CA | |
| SCHEMBL30253232 | 0.73 | F10 (0.41) | MTORCYP11B2MAP4K1JAK2JAK1 | |
| SCHEMBL5740638 | 0.72 | PTGS2 (0.48) | MTORCYP11B2F10HDAC1PIK3CA | |
| SCHEMBL21929346 | 0.69 | GAA (0.67) | JAK2F10 | |
| SCHEMBL1677899 | 0.69 | F10 (0.60) | F10 | |
| SCHEMBL13718737 | 0.68 | MTOR (0.72) | MTOR | |
| SCHEMBL24157096 | 0.67 | TYK2 (0.46) | MTORJAK2JAK1TYK2JAK3 | |
| SCHEMBL30369246 | 0.67 | TYK2 (0.46) | MTORJAK2JAK1TYK2JAK3 | |
| SCHEMBL24156727 | 0.66 | F10 (0.44) | MTORJAK2JAK1TYK2JAK3 | |
| SCHEMBL30369639 | 0.66 | F10 (0.44) | MTORJAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115715288-A | TYK-2 inhibitors | 百济神州有限公司 | 2023-02-24 | — | — | CN | disclosed |