Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 15/20 | 0.68 |
| ▸ | PTGDR | Q13258 | 8/20 | 0.68 |
| ▸ | TBXA2R | P21731 | 7/20 | 0.68 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.66 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.66 |
| ▸ | DRD1 | P21728 | 1/20 | 0.66 |
| ▸ | CCKAR | P32238 | 1/20 | 0.66 |
| ▸ | RB1 | P06400 | 1/20 | 0.51 |
| ▸ | HTR6 | P50406 | 2/20 | 0.45 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR7 | P34969 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7588135 | 1.00 | PTGDR2 (0.68) | PTGDR2PTGDRTBXA2RCYP2C9ABCB11 | |
| SCHEMBL2778488 | 0.88 | PTGDR2 (0.55) | PTGDR2PTGDRTBXA2RCYP2C9ABCB11 | |
| SCHEMBL9989741 | 0.88 | PTGDR2 (0.53) | PTGDR2PTGDRTBXA2RCYP2C9ABCB11 | |
| SCHEMBL2775919 | 0.86 | PTGDR2 (0.55) | PTGDR2PTGDRTBXA2RCYP2C9ABCB11 | |
| SCHEMBL9989737 | 0.86 | PTGDR2 (0.53) | PTGDR2PTGDRTBXA2RCYP2C9ABCB11 | |
| SCHEMBL30608801 | 0.81 | PTGDR2 (0.70) | PTGDR2PTGDRTBXA2RCYP2C9HTR6 | |
| SCHEMBL16558830 | 0.81 | PTGDR2 (1.00) | PTGDR2PTGDRTBXA2RCYP2C9ABCB11 | |
| SCHEMBL18456875 | 0.81 | PTGDR2 (1.00) | PTGDR2PTGDRTBXA2RCYP2C9ABCB11 | |
| Bicarbonate SCHEMBL9562296 | 0.81 | PTGDR2 (0.82) | PTGDR2PTGDRTBXA2RCYP2C9ABCB11 | |
| Ramatroban SCHEMBL29030 | 0.80 | PTGDR2 (1.00) | PTGDR2PTGDRTBXA2RCYP2C9ABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 44 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3350179-B1 | CRYSTALLINE FORMS | IDORSIA PHARMACEUTICALS LTD (CH) | 2021-01-13 | — | — | EP | disclosed |
| US-10351560-B2 | Crystalline forms | IDORSIA PHARMACEUTICALS LTD (CH) | 2019-07-16 | — | — | US | disclosed |
| US-10301309-B2 | Azaindole acetic acid derivatives and their use as prostaglandin D2 receptor modulators | IDORSIA PHARMACEUTICALS LTD (CH) | 2019-05-28 | — | — | US | disclosed |
| US-20190047996-A1 | CRYSTALLINE FORMS | IDORSIA PHARMACEUTICALS LTD. (CH) | 2019-02-14 | — | — | US | disclosed |
| CN-106103435-B | The purposes of azaindole acetogenin and they as prostaglandin D 2 receptor regulator | 爱杜西亚药品有限公司 | 2018-11-16 | — | — | CN | disclosed |
| EP-3119780-B1 | AZAINDOLE ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2018-08-29 | — | — | EP | disclosed |
| EP-3350179-A1 | CRYSTALLINE FORMS | Idorsia Pharmaceuticals Ltd (CH) | 2018-07-25 | — | — | EP | disclosed |
| EP-3119779-B1 | AZAINDOLE ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | IDORSIA PHARMACEUTICALS LTD (CH) | 2018-07-11 | — | — | EP | disclosed |
| CN-108026093-A | Crystal form | 爱杜西亚药品有限公司 | 2018-05-11 | — | — | CN | disclosed |
| US-20180105520-A1 | AZAINDOLE ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | ACTELION PHARMACEUTICALS LTD (CH) | 2018-04-19 | — | — | US | disclosed |
| US-8273740-B2 | antiallergen; not direct way to change nature of immunological response to allergen; G-protein-coupled \"chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)\" antagonist for prostaglandin PGD2, that mediates PGD2-dependent migration of blood Th2 cells; ; asthma, rhinitis, COPD | ACTELION PHARMACEUTICALS, LTD. (CH) | 2012-09-25 | — | — | US | disclosed |
| US-20100190830-A1 | (3-Amino-1,2,3,4-Tetrahydro-9H-Carbazol-9-yl)-Acetic Acid Derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2010-07-29 | — | — | US | disclosed |
| EP-1740171-B1 | INDOL-1-YL-ACETIC ACID DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2010-06-09 | — | — | EP | disclosed |
| US-7714132-B2 | Tetrahydropyridoindole derivatives | ACTELION PHARMACEUTICALS, LTD. (CH) | 2010-05-11 | — | — | US | disclosed |
| US-20090270414-A1 | 2,3,4,9- TETRAHYDRO-1H-CARBAZOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS | ACTELION PHARMACEUTICALS LTD. (CH) | 2009-10-29 | — | — | US | disclosed |
| US-20080108638-A1 | 2-Sulfanyl-Benzoimidazol-1-Yl-Acetic Acid Derivatives as Crth2 Antagonists | ACTELION PHARMACEUTICALS,LTD. (CH) | 2008-05-08 | — | — | US | disclosed |
| EP-1725553-B1 | TETRAHYDROPYRIDOINDOLE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2008-05-07 | — | — | EP | disclosed |
| US-20070208004-A1 | Indol-1-yl-acetic acid derivatives | ACTELION PHARMACEUTICALS, LTD. (CH) | 2007-09-06 | — | — | US | disclosed |
| US-20070191416-A1 | Tetrahydropyridoindole derivatives | IDORSIA PHARMACEUTICALS LTD (CH) | 2007-08-16 | — | — | US | disclosed |
| US-5684158-A | 3-amino!-tetrahydrocarbazole-propanoic acid esters | BAYER AKTIENGESELLSCHAFT (DE) | 1997-11-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080108638-A1 | 2-Sulfanyl-Benzoimidazol-1-Yl-Acetic Acid Derivatives as Crth2 Antagonists | HRH2, HRH1, HRH3 | PTGDR2 12/4885PTGDR 32/4885TBXA2R 20/4885 |
| US-20100190830-A1 | (3-Amino-1,2,3,4-Tetrahydro-9H-Carbazol-9-yl)-Acetic Acid Derivatives | PTGDR, PTGER1, PTGIR | PTGDR2 4/4885PTGDR 1/4885TBXA2R 7/4885 |
| US-20090270414-A1 | 2,3,4,9- TETRAHYDRO-1H-CARBAZOLE DERIVATIVES AS CRTH2 RECEPTOR ANTAGONISTS | HRH2, CRHR2, GRK2 | PTGDR2 36/4885PTGDR 42/4885TBXA2R 9/4885 |
| US-10301309-B2 | Azaindole acetic acid derivatives and their use as prostaglandin D2 receptor modulators | PTGDR, PTGDR2, PTGER2 | PTGDR2 2/4885PTGDR 1/4885TBXA2R 9/4885 |
| US-20070208004-A1 | Indol-1-yl-acetic acid derivatives | IDO1, IDO2, AANAT | PTGDR2 2853/4885PTGDR 2419/4885TBXA2R 1495/4885 |
| US-20180105520-A1 | AZAINDOLE ACETIC ACID DERIVATIVES AND THEIR USE AS PROSTAGLANDIN D2 RECEPTOR MODULATORS | PTGDR, PTGDR2, PTGER2 | PTGDR2 2/4885PTGDR 1/4885TBXA2R 9/4885 |
| US-20190047996-A1 | CRYSTALLINE FORMS | HRH2, HRH1, HRH3 | PTGDR2 200/4885PTGDR 254/4885TBXA2R 99/4885 |
| US-10351560-B2 | Crystalline forms | HRH2, HRH1, HRH3 | PTGDR2 200/4885PTGDR 254/4885TBXA2R 99/4885 |
| US-20070191416-A1 | Tetrahydropyridoindole derivatives | TPH2, TPH1, HTR2C | PTGDR2 154/4885PTGDR 119/4885TBXA2R 121/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.