Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR1 | Q9BXC0 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.38 |
| ▸ | BAD | Q92934 | 1/20 | 0.38 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | DHFR | P00374 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30121400 | 0.70 | ALDH1A1 (0.38) | HCAR1ALDH1A1HPGDSMN1; SMN2NPBWR1 | |
| SCHEMBL9506638 | 0.67 | BCL2L1 (0.47) | ALDH1A1HPGDSMN1; SMN2BCL2L1BAD | |
| SCHEMBL16458811 | 0.67 | NUDT1 (0.46) | — | |
| SCHEMBL30791244 | 0.67 | HCAR1 (0.40) | HCAR1ALDH1A1HPGDSMN1; SMN2ROCK1 | |
| SCHEMBL31207337 | 0.66 | HCAR1 (0.38) | HCAR1ALDH1A1HPGDSMN1; SMN2ROCK1 | |
| SCHEMBL4884376 | 0.66 | FLT3 (0.48) | HCAR1ALDH1A1HPGDKMT2A | |
| SCHEMBL3801550 | 0.66 | BCL2L1 (0.54) | ALDH1A1HPGDSMN1; SMN2BCL2L1BAD | |
| SCHEMBL7952487 | 0.66 | BCL2L1 (0.54) | ALDH1A1HPGDSMN1; SMN2BCL2L1BAD | |
| SCHEMBL10789537 | 0.66 | BCL2L1 (0.54) | ALDH1A1HPGDSMN1; SMN2BCL2L1BAD | |
| SCHEMBL5923921 | 0.65 | ALDH1A1 (0.49) | ALDH1A1HPGDSMN1; SMN2ROCK1BCL2L1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4138823-A1 | METHOD OF SELECTING PATIENTS FOR TREATMENT WITH A COMBINATION OF AN AXL INHIBITOR AND AN IMMUNE CHECKPOINT MODULATOR | BerGenBio ASA (NO) | 2023-03-01 | — | — | EP | disclosed |