Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.47 |
| ▸ | BAD | Q92934 | 1/20 | 0.47 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 3/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 4/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5691238 | 0.96 | KEAP1 (0.46) | BCL2L1BADDPP4KEAP1MAPK1 | |
| SCHEMBL5371599 | 0.86 | ADRB1 (0.51) | HTR2CHTR2BALDH1A1HPGDHTR1A | |
| SCHEMBL14591333 | 0.85 | HTR1A (0.54) | BCL2L1BADDPP4MAPK1HTR2C | |
| SCHEMBL2348878 | 0.84 | ADRB1 (0.53) | HTR2CHTR2BALDH1A1HPGDHTR1A | |
| Hydrochloric Acid SCHEMBL5247444 | 0.82 | ADRB1 (0.51) | HTR2CHTR2BALDH1A1HPGDHTR1A | |
| Hydrochloric Acid SCHEMBL8572545 | 0.82 | ADRB1 (0.51) | HTR2CHTR2BALDH1A1HPGDHTR1A | |
| SCHEMBL2056184 | 0.81 | HTR1A (0.51) | DPP4MAPK1HTR2CHTR1AHTR1D | |
| SCHEMBL5426797 | 0.80 | HCAR1 (0.42) | BCL2L1BADDPP4HTR2CHTR2B | |
| SCHEMBL4688382 | 0.80 | ADRB1 (0.53) | HTR2CHTR2BALDH1A1HPGDHTR1A | |
| SCHEMBL5691201 | 0.80 | ALDH1A1 (0.43) | BCL2L1BADDPP4ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0552246-A1 | THERAPEUTICALLY USEFUL 2-AMINOTETRALIN DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 1993-07-28 | — | — | EP | claimed |
| WO-1992006967-A1 | THERAPEUTICALLY USEFUL 2-AMINOTETRALIN DERIVATIVES | THE UPJOHN COMPANY (US) | 1992-04-30 | — | — | WO | claimed |