Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 4/20 | 0.33 |
| ▸ | JAK1 | P23458 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.31 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.31 |
| ▸ | TYK2 | P29597 | 3/20 | 0.31 |
| ▸ | JAK3 | P52333 | 3/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
| ▸ | SYK | P43405 | 1/20 | 0.30 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30538800 | 0.87 | MEN1 (0.32) | JAK2JAK1MEN1KMT2ATYK2 | |
| SCHEMBL30680673 | 0.86 | PTGER4 (0.35) | MEN1KMT2APTGER4USP2LMNA | |
| SCHEMBL29993091 | 0.79 | BRD4 (0.41) | USP2LMNAMAPK1CYP11B2 | |
| SCHEMBL25005199 | 0.78 | LMNA (0.35) | MKNK2JAK2JAK1PTGER4LMNA | |
| SCHEMBL30882773 | 0.78 | LMNA (0.35) | MKNK2JAK2JAK1PTGER4LMNA | |
| SCHEMBL30125053 | 0.74 | CYP1A2 (0.39) | MEN1KMT2ATSHR | |
| SCHEMBL30538743 | 0.73 | KMT2A (0.42) | MEN1KMT2APTGER4TSHRMAPK1 | |
| SCHEMBL29079758 | 0.73 | ALDH1A1 (0.40) | MEN1KMT2APTGER4TSHRMAPK1 | |
| SCHEMBL29558931 | 0.73 | ALDH1A1 (0.40) | MEN1KMT2APTGER4TSHRMAPK1 | |
| SCHEMBL29079760 | 0.73 | ALDH1A1 (0.40) | MEN1KMT2APTGER4TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118974037-A | Benzobicyclo compound and preparation method and application thereof | 广州市联瑞制药有限公司 | 2024-11-15 | — | — | CN | disclosed |
| CN-117242067-A | Novel aryl ether substituted heterocycles as GLP1R agonists | 杭州德睿智药科技有限公司 | 2023-12-15 | — | — | CN | disclosed |
| WO-2023169436-A1 | BENZO BICYCLIC COMPOUND, AND PREPARATION METHOD AND APPLICATION THEREOF | 广州市联瑞制药有限公司 | 2023-09-14 | — | — | WO | disclosed |
| WO-2023011539-A1 | CYCLOALKENE DERIVATIVE REGULATOR, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF | 上海翰森生物医药科技有限公司 | 2023-02-09 | — | — | WO | disclosed |