Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 2/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.34 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.34 |
| ▸ | DHFR | P00374 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31211626 | 0.81 | PTGS2 (0.47) | PTGS2CYP11B1CYP11B2ALDH1A1KDM4E | |
| SCHEMBL7180542 | 0.70 | PTGS2 (0.67) | PTGS2CYP11B1CYP11B2DRD4IP6K1 | |
| SCHEMBL29672905 | 0.70 | PTGS2 (0.67) | PTGS2CYP11B1CYP11B2DRD4IP6K1 | |
| SCHEMBL8080061 | 0.70 | PTGS2 (0.62) | PTGS2CYP11B1CYP11B2DRD4ALDH1A1 | |
| SCHEMBL30666896 | 0.70 | PTGS2 (0.62) | PTGS2CYP11B1CYP11B2DRD4ALDH1A1 | |
| SCHEMBL7181762 | 0.69 | PTGS2 (0.57) | PTGS2CYP11B1CYP11B2DRD4TDP1 | |
| SCHEMBL7172726 | 0.69 | PTGS2 (0.65) | PTGS2CYP11B1CYP11B2DRD4IP6K1 | |
| SCHEMBL29606538 | 0.69 | PTGS2 (0.65) | PTGS2CYP11B1CYP11B2DRD4IP6K1 | |
| SCHEMBL7205941 | 0.68 | PTGS2 (0.57) | PTGS2CYP11B1CYP11B2DRD4TSHR | |
| SCHEMBL30664496 | 0.68 | PTGS2 (0.57) | PTGS2CYP11B1CYP11B2DRD4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230047816-A1 | PFKFB3 INHIBITORS AND THEIR USES | GERO PTE. LTD. (SG) | 2023-02-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230047816-A1 | PFKFB3 INHIBITORS AND THEIR USES | PFKFB3, PFKFB4, PFKFB1 | PTGS2 861/4885CYP11B1 2400/4885CYP11B2 2502/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.