Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PROKR1 | Q8TCW9 | 1/20 | 0.35 |
| ▸ | CTSD | P07339 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3377977 | 0.80 | LMNA (0.52) | LMNAHPGDKMT2AALDH1A1MEN1 | |
| SCHEMBL3377147 | 0.80 | PROKR1 (0.52) | LMNASMN1; SMN2HPGDKMT2AALDH1A1 | |
| SCHEMBL3380454 | 0.75 | ALDH1A1 (0.58) | LMNASMN1; SMN2HPGDKMT2AALDH1A1 | |
| SCHEMBL3375719 | 0.73 | LMNA (0.60) | LMNAKMT2AALDH1A1MEN1MAPT | |
| SCHEMBL303313 | 0.72 | LMNA (0.57) | LMNAHPGDKMT2AALDH1A1MEN1 | |
| SCHEMBL302061 | 0.71 | LMNA (0.54) | LMNASMN1; SMN2HPGDKMT2AALDH1A1 | |
| SCHEMBL3380407 | 0.71 | LMNA (0.64) | LMNAKMT2AALDH1A1MEN1MAPT | |
| SCHEMBL302132 | 0.70 | ALDH1A1 (0.65) | LMNASMN1; SMN2HPGDKMT2AALDH1A1 | |
| SCHEMBL3379800 | 0.68 | LMNA (0.58) | LMNASMN1; SMN2KMT2AALDH1A1MEN1 | |
| SCHEMBL3377290 | 0.68 | LMNA (0.57) | LMNASMN1; SMN2KMT2AALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2012500836-A | — | — | 2012-01-12 | — | — | JP | claimed |
| EP-2342177-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-07-13 | — | — | EP | claimed |
| WO-2010023448-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | XENTION LIMITED (GB) | 2010-03-04 | — | — | WO | claimed |