Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 5/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 5/20 | 0.43 |
| ▸ | HTR1A | P08908 | 7/20 | 0.43 |
| ▸ | HTR7 | P34969 | 6/20 | 0.43 |
| ▸ | DRD2 | P14416 | 4/20 | 0.43 |
| ▸ | HTR6 | P50406 | 3/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26218354 | 0.94 | ADRA1A (0.44) | ADRA1AADRA1BHTR1AHTR7DRD2 | |
| SCHEMBL26213163 | 0.91 | KDM4E (0.41) | HTR1AHTR7DRD2HTR6SIGMAR1 | |
| SCHEMBL30270490 | 0.88 | ADRA1A (0.45) | ADRA1AADRA1BHTR1AHTR7DRD2 | |
| SCHEMBL26213175 | 0.87 | SRC (0.46) | HTR1AHTR7DRD2HTR6SIGMAR1 | |
| SCHEMBL26213157 | 0.87 | HTR1A (0.48) | ADRA1AADRA1BHTR1AHTR7DRD2 | |
| SCHEMBL30270444 | 0.86 | HTR1A (0.37) | HTR1AHTR7DRD2HTR6SIGMAR1 | |
| SCHEMBL26213193 | 0.86 | HTR1A (0.37) | HTR1AHTR7DRD2HTR6SIGMAR1 | |
| SCHEMBL26213178 | 0.83 | HTR7 (0.47) | HTR1AHTR7DRD2HTR6SIGMAR1 | |
| SCHEMBL26218485 | 0.83 | ADRA1A (0.45) | ADRA1AADRA1BHTR1AHTR7HTR6 | |
| SCHEMBL30270553 | 0.83 | HTR6 (0.49) | ADRA1AADRA1BHTR1AHTR6HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115843271-B | Indole derivatives and their use for the treatment of cancer | 克洛德贝纳尔-里昂第一大学 | 2024-08-13 | — | — | CN | disclosed |
| EP-4175718-A1 | INDOLE DERIVATIVES AND USES THEREOF FOR TREATING A CANCER | UNIVERSITE CLAUDE BERNARD - LYON 1 (FR) | 2023-05-10 | — | — | EP | disclosed |
| CN-115843271-A | Indole derivatives and their use for the treatment of cancer | 克洛德贝纳尔-里昂第一大学 | 2023-03-24 | — | — | CN | disclosed |