Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.32 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.32 |
| ▸ | OXTR | P30559 | 1/20 | 0.32 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.32 |
| ▸ | RARB | P10826 | 2/20 | 0.32 |
| ▸ | CHKA | P35790 | 1/20 | 0.31 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | CTSV | O60911 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3031793 | 0.99 | HRH3 (0.38) | HRH3S1PR1HSD11B1OPRL1ASAH1 | |
| SCHEMBL13694878 | 0.99 | S1PR1 (0.36) | HRH3S1PR1HSD11B1OPRL1ASAH1 | |
| SCHEMBL3034775 | 0.94 | HRH3 (0.35) | HRH3S1PR1AVPR2OXTRAVPR1A | |
| SCHEMBL13219241 | 0.90 | HRH3 (0.33) | HRH3S1PR1RARB | |
| SCHEMBL13219237 | 0.89 | HRH3 (0.33) | HRH3HSD11B1AVPR2OXTRAVPR1A | |
| SCHEMBL3037414 | 0.88 | TP53 (0.37) | HRH3MAPK1 | |
| SCHEMBL3036691 | 0.88 | THRA (0.37) | HRH3 | |
| SCHEMBL3037388 | 0.87 | PTGDR (0.38) | KDM4EALDH1A1MAPTHPGDMAPK1 | |
| SCHEMBL3026766 | 0.86 | RARB (0.36) | HSD11B1ASAH1RARBALDH1A1MAPT | |
| SCHEMBL13694880 | 0.86 | HTR7 (0.32) | KDM4EALDH1A1MAPTHPGDMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9249136-B2 | 3H-naphtho [2,1-B] pyrans as photochromic dichroic dyes and optical article containing them | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2016-02-02 | — | — | US | disclosed |
| US-9249136-B2 | 3H-naphtho [2,1-B] pyrans as photochromic dichroic dyes and optical article containing them | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2016-02-02 | — | — | US | disclosed |
| EP-2066650-B1 | 3H-NAPHTHO[2,1-B]PYRANS AS PHOTOCHROMIC DICHROIC DYES AND OPTICAL ARTICLE CONTAINING THEM | ESSILOR INT (FR) | 2011-12-21 | — | — | EP | disclosed |
| US-20100202033-A1 | 3H-NAPHTH0 [2,1-B] PYRANS AS PHOTOCHROMIC DICHROIC DYES AND OPTICAL ARTICLE CONTAINING THEM | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D' OPTIQUE) (FR) | 2010-08-12 | — | — | US | disclosed |
| US-20100202033-A1 | 3H-NAPHTH0 [2,1-B] PYRANS AS PHOTOCHROMIC DICHROIC DYES AND OPTICAL ARTICLE CONTAINING THEM | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D' OPTIQUE) (FR) | 2010-08-12 | — | — | US | disclosed |
| EP-2066650-A1 | 3H-NAPHTH0 [2, 1-B]PYRANS AS PHOTOCHROMIC DICHROIC DYES AND OPTICAL ARTICLE CONTAINING THEM | ESSILOR INTERNATIONAL (Compagnie Générale d'Optique) (FR) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008030226-A1 | 3H-NAPHTH0 [2, 1-B] PYRANS AS PHOTOCHROMIC DICHROIC DYES AND OPTICAL ARTICLE CONTAINING THEM | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2008-03-13 | — | — | WO | disclosed |
| WO-2008030226-A1 | 3H-NAPHTH0 [2, 1-B] PYRANS AS PHOTOCHROMIC DICHROIC DYES AND OPTICAL ARTICLE CONTAINING THEM | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2008-03-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100202033-A1 | 3H-NAPHTH0 [2,1-B] PYRANS AS PHOTOCHROMIC DICHROIC DYES AND OPTICAL ARTICLE CONTAINING THEM | NR0B1, NR0B2, NR4A1 | HRH3 533/4885S1PR1 932/4885HSD11B1 187/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.