Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 3/20 | 0.34 |
| ▸ | HTR2A | P28223 | 3/20 | 0.34 |
| ▸ | DRD3 | P35462 | 3/20 | 0.34 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | DRD5 | P21918 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 2/20 | 0.32 |
| ▸ | IKBKB | O14920 | 1/20 | 0.32 |
| ▸ | RARB | P10826 | 1/20 | 0.32 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.30 |
| ▸ | OXTR | P30559 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3027348 | 0.94 | HRH3 (0.36) | HRH3S1PR1CNR1RARBAVPR2 | |
| SCHEMBL3031793 | 0.94 | HRH3 (0.38) | HRH3S1PR1CNR1RARBAVPR2 | |
| SCHEMBL13694878 | 0.93 | S1PR1 (0.36) | HRH3S1PR1CNR1RARBAVPR2 | |
| SCHEMBL13219241 | 0.91 | HRH3 (0.33) | HRH3S1PR1RARB | |
| SCHEMBL3026766 | 0.89 | RARB (0.36) | HTR2ARARB | |
| SCHEMBL3037388 | 0.85 | PTGDR (0.38) | — | |
| SCHEMBL13219237 | 0.84 | HRH3 (0.33) | HRH3RARBAVPR2OXTRAVPR1A | |
| SCHEMBL3037414 | 0.83 | TP53 (0.37) | HRH3HRH1 | |
| SCHEMBL3036691 | 0.82 | THRA (0.37) | HRH3DRD3DRD2HRH1DRD4 | |
| SCHEMBL13694880 | 0.80 | HTR7 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9249136-B2 | 3H-naphtho [2,1-B] pyrans as photochromic dichroic dyes and optical article containing them | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2016-02-02 | — | — | US | disclosed |
| EP-2066650-B1 | 3H-NAPHTHO[2,1-B]PYRANS AS PHOTOCHROMIC DICHROIC DYES AND OPTICAL ARTICLE CONTAINING THEM | ESSILOR INT (FR) | 2011-12-21 | — | — | EP | disclosed |
| US-20100202033-A1 | 3H-NAPHTH0 [2,1-B] PYRANS AS PHOTOCHROMIC DICHROIC DYES AND OPTICAL ARTICLE CONTAINING THEM | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D' OPTIQUE) (FR) | 2010-08-12 | — | — | US | disclosed |
| EP-2066650-A1 | 3H-NAPHTH0 [2, 1-B]PYRANS AS PHOTOCHROMIC DICHROIC DYES AND OPTICAL ARTICLE CONTAINING THEM | ESSILOR INTERNATIONAL (Compagnie Générale d'Optique) (FR) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008030226-A1 | 3H-NAPHTH0 [2, 1-B] PYRANS AS PHOTOCHROMIC DICHROIC DYES AND OPTICAL ARTICLE CONTAINING THEM | ESSILOR INTERNATIONAL (COMPAGNIE GENERALE D'OPTIQUE) (FR) | 2008-03-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100202033-A1 | 3H-NAPHTH0 [2,1-B] PYRANS AS PHOTOCHROMIC DICHROIC DYES AND OPTICAL ARTICLE CONTAINING THEM | NR0B1, NR0B2, NR4A1 | HRH3 533/4885HTR1A 367/4885HTR2A 1673/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.