Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 12/20 | 0.60 |
| ▸ | RAB9A | P51151 | 5/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.60 |
| ▸ | NPC1 | O15118 | 4/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.47 |
| ▸ | DHFR | P00374 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3023133 | 0.76 | MAPT (0.58) | MAPTRAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL29656856 | 0.72 | HTR3E (0.73) | MAPTRAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL28599511 | 0.72 | HTR3E (0.73) | MAPTRAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL3017262 | 0.71 | PSEN1 (0.49) | MAPTRAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL12265056 | 0.71 | DRD2 (0.65) | MAPTRAB9ASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL28432321 | 0.70 | MAPT (0.64) | MAPTRAB9ASMN1; SMN2ALDH1A1KMT2A | |
| SCHEMBL9311925 | 0.70 | ALDH1A1 (0.58) | MAPTRAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL2493902 | 0.69 | KMT2A (0.57) | MAPTRAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL11066512 | 0.68 | MAPT (0.69) | MAPTRAB9ASMN1; SMN2NPC1ALDH1A1 | |
| SCHEMBL8353109 | 0.68 | DRD2 (0.75) | MAPTRAB9ASMN1; SMN2ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100204230-A1 | PIPERAZINE DERIVATIVES FOR TREATMENT OF AD AND RELATED CONDITIONS | MERCK SHARP & DOHME CORP. | 2010-08-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100204230-A1 | PIPERAZINE DERIVATIVES FOR TREATMENT OF AD AND RELATED CONDITIONS | PSEN1, PSEN2, APP | MAPT 8/4885RAB9A 2806/4885SMN1; SMN2 1587/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.