Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 4/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.35 |
| ▸ | CDK2 | P24941 | 4/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 4/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | PLK1 | P53350 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | RET | P07949 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | CDC7 | O00311 | 1/20 | 0.30 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30281146 | 0.87 | PIK3CA (0.33) | PIK3CAPIK3CDPIK3CGATM | |
| SCHEMBL23990554 | 0.84 | ATM (0.35) | PIK3CAPIK3CDPIK3CGATMADRA1A | |
| SCHEMBL23990535 | 0.79 | NPC1 (0.33) | PIK3CAPIK3CDPIK3CGRETADRA1A | |
| SCHEMBL12498978 | 0.77 | PDE4B (0.33) | PIK3CAPIK3CDPIK3CGKMT2A | |
| SCHEMBL30281196 | 0.76 | ABL1 (0.32) | PIK3CA | |
| SCHEMBL30281185 | 0.76 | HDAC1 (0.31) | PIK3CA | |
| SCHEMBL30281273 | 0.75 | CNR1 (0.32) | — | |
| SCHEMBL3473167 | 0.74 | TSHR (0.33) | — | |
| SCHEMBL31708457 | 0.72 | ADRA1A (0.33) | PIK3CAADRA1A | |
| SCHEMBL30209669 | 0.71 | SIRT2 (0.36) | PIK3CASRCRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4143195-A1 | IMIDAZOPYRIDAZINES AS MODULATORS OF IL-17 | Janssen Pharmaceutica NV (BE) | 2023-03-08 | — | — | EP | disclosed |