Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | GBA1 | P04062 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.33 |
| ▸ | PDE1A | P54750 | 1/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.33 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.33 |
| ▸ | CD38 | P28907 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.32 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.32 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.32 |
| ▸ | CHUK | O15111 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25850497 | 1.00 | JAK2 (0.36) | JAK2JAK1GBA1IDH1CTSK | |
| SCHEMBL24154957 | 1.00 | JAK2 (0.36) | JAK2JAK1GBA1IDH1CTSK | |
| SCHEMBL25306451 | 1.00 | JAK2 (0.36) | JAK2JAK1GBA1IDH1CTSK | |
| SCHEMBL25306447 | 1.00 | JAK2 (0.36) | JAK2JAK1GBA1IDH1CTSK | |
| SCHEMBL24154923 | 0.86 | JAK2 (0.38) | JAK2JAK1GBA1IDH1CTSK | |
| SCHEMBL24155296 | 0.86 | JAK2 (0.38) | JAK2JAK1GBA1IDH1CTSK | |
| SCHEMBL25307503 | 0.86 | JAK2 (0.38) | JAK2JAK1GBA1IDH1CTSK | |
| SCHEMBL30283042 | 0.82 | ALDH1A1 (0.39) | JAK2JAK1GBA1IDH1CTSK | |
| SCHEMBL24154769 | 0.78 | CTSK (0.42) | CTSKALDH1A1MBOAT4PDE1APDE1B | |
| SCHEMBL30319984 | 0.78 | CTSK (0.42) | CTSKALDH1A1MBOAT4PDE1APDE1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4168394-A1 | AMIDOPYRIMIDONE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2023-04-26 | — | — | EP | disclosed |
| CN-115867541-A | Aminopyrimidinone derivatives | 豪夫迈·罗氏有限公司 | 2023-03-28 | — | — | CN | disclosed |