Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 5/20 | 0.44 |
| ▸ | BCHE | P06276 | 3/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | KAT7 | O95251 | 1/20 | 0.40 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | YAP1 | P46937 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29269458 | 1.00 | HTR6 (0.44) | HTR6BCHEGPR119ALDH1A1L3MBTL1 | |
| SCHEMBL29269459 | 1.00 | HTR6 (0.44) | HTR6BCHEGPR119ALDH1A1L3MBTL1 | |
| SCHEMBL29269498 | 0.92 | HTR6 (0.44) | HTR6BCHEGPR119ACKR3USP30 | |
| SCHEMBL29269496 | 0.92 | HTR6 (0.44) | HTR6BCHEGPR119ACKR3USP30 | |
| SCHEMBL29269379 | 0.91 | HTR6 (0.45) | HTR6BCHEALDH1A1L3MBTL1ACKR3 | |
| SCHEMBL29269376 | 0.91 | HTR6 (0.45) | HTR6BCHEALDH1A1L3MBTL1ACKR3 | |
| SCHEMBL29269477 | 0.89 | HTR6 (0.45) | HTR6BCHEGPR119ACKR3USP30 | |
| SCHEMBL30283224 | 0.89 | HTR6 (0.45) | HTR6BCHEGPR119ACKR3USP30 | |
| SCHEMBL29269478 | 0.89 | HTR6 (0.45) | HTR6BCHEGPR119ACKR3USP30 | |
| SCHEMBL29269489 | 0.87 | YAP1 (0.42) | HTR6BCHEGPR119KAT7KAT8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4301736-A1 | MACROCYCLIC COMPOUNDS AS PROTEASOME SUBUNIT BETA TYPE-5 INHIBITORS | Lead Discovery Center GmbH (DE) | 2024-01-10 | — | — | EP | disclosed |
| WO-2023046939-A1 | MACROCYCLIC COMPOUNDS AS PROTEASOME SUBUNIT BETA TYPE-5 INHIBITORS | LEAD DISCOVERY CENTER GMBH (DE) | 2023-03-30 | — | — | WO | disclosed |