Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.50 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | DHPS | P49366 | 1/20 | 0.49 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.49 |
| ▸ | TUBB | P07437 | 1/20 | 0.49 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.49 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.49 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.49 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.49 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.49 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.49 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.49 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.49 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.49 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.49 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.49 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.49 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.49 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL40257 | 0.98 | NAPRT (0.52) | KEAP1NAPRTMAPK14DHPSTUBB4A | |
| SCHEMBL29684913 | 0.98 | NAPRT (0.52) | KEAP1NAPRTMAPK14DHPSTUBB4A | |
| Hydrochloric Acid SCHEMBL1374882 | 0.96 | KEAP1 (0.50) | KEAP1NAPRTMAPK14DHPSTUBB4A | |
| Sulfuric Acid SCHEMBL28227778 | 0.88 | MAPK14 (0.44) | KEAP1NAPRTMAPK14DHPSTUBB4A | |
| Pyridine SCHEMBL9319094 | 0.88 | PIK3CD (0.49) | KEAP1NAPRTMAPK14DHPSTUBB4A | |
| Trifluoroacetic Acid SCHEMBL2039025 | 0.88 | MAPK1 (0.47) | KEAP1NAPRTMAPK14DHPSTUBB4A | |
| SCHEMBL3001554 | 0.84 | TUBB4A (0.60) | DHPSTUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL1570156 | 0.82 | FTO (0.56) | KEAP1NAPRTMAPK14DHPSFTO | |
| SCHEMBL827588 | 0.81 | PBRM1 (0.59) | MAPK14DHPSTUBB4ATUBBTUBA3C | |
| SCHEMBL9871918 | 0.81 | MAPK14 (0.49) | MAPK14DHPSTUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4396176-A1 | INDOLE COMPOUNDS AND USES THEREOF IN THE TREATEMENT OF CYSTIC FIBROSIS | GENZYME CORPORATION (US) | 2024-07-10 | — | — | EP | disclosed |
| WO-2023034946-A1 | INDOLE COMPOUNDS AND USES THEREOF IN THE TREATEMENT OF CYSTIC FIBROSIS | GENZYME CORPORATION (US) | 2023-03-09 | — | — | WO | disclosed |