Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1723221 | 0.87 | GRM5 (0.49) | GRM5HPGDGAAALDH1A1POLB | |
| SCHEMBL327168 | 0.85 | LMNA (0.48) | HPGDGAAALDH1A1HRH3LMNA | |
| SCHEMBL303461 | 0.85 | LMNA (0.43) | GRM5HPGDGAAALDH1A1POLB | |
| SCHEMBL1722509 | 0.82 | PROKR1 (0.47) | HPGDALDH1A1LMNAKMT2A | |
| SCHEMBL3281840 | 0.82 | KMT2A (0.51) | HPGDALDH1A1MEN1KMT2ACNR1 | |
| SCHEMBL1722907 | 0.81 | LMNA (0.44) | HPGDGAAALDH1A1POLBLMNA | |
| SCHEMBL305968 | 0.79 | LMNA (0.42) | HPGDGAAALDH1A1LMNAMEN1 | |
| SCHEMBL303609 | 0.79 | TP53 (0.46) | HPGDALDH1A1POLBCA12CA1 | |
| SCHEMBL327423 | 0.78 | POLB (0.46) | GRM5HPGDGAAALDH1A1POLB | |
| SCHEMBL1710991 | 0.78 | LMNA (0.47) | HPGDGAAALDH1A1CA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2012500834-A | — | — | 2012-01-12 | — | — | JP | claimed |
| EP-2344456-A1 | NOVEL POTASSIUM CHANNEL BLOCKER | Xention Limited (GB) | 2011-07-20 | — | — | EP | claimed |
| EP-2344456-A1 | NOVEL POTASSIUM CHANNEL BLOCKER | Xention Limited (GB) | 2011-07-20 | — | — | EP | disclosed |