Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 6/20 | 0.40 |
| ▸ | CNR1 | P21554 | 5/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | LSS | P48449 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3274787 | 0.86 | LMNA (0.52) | LMNAHPGDKMT2AHTTSMN1; SMN2 | |
| SCHEMBL327168 | 0.86 | LMNA (0.48) | LMNAHPGDKMT2ACNR2CNR1 | |
| SCHEMBL303461 | 0.82 | LMNA (0.43) | LMNAHPGDKMT2ACNR2CNR1 | |
| SCHEMBL1723221 | 0.81 | GRM5 (0.49) | LMNAHPGDKMT2AHTTSMN1; SMN2 | |
| SCHEMBL3281840 | 0.81 | KMT2A (0.51) | HPGDKMT2ACNR2CNR1ALDH1A1 | |
| SCHEMBL302862 | 0.79 | GRM5 (0.42) | LMNAHPGDKMT2ACNR2CNR1 | |
| SCHEMBL1722897 | 0.79 | LMNA (0.45) | LMNAHPGDKMT2ASLC6A9HTT | |
| SCHEMBL1722509 | 0.79 | PROKR1 (0.47) | LMNAHPGDKMT2AALDH1A1 | |
| SCHEMBL1725940 | 0.78 | LMNA (0.47) | LMNAHPGDKMT2AHTTSMN1; SMN2 | |
| SCHEMBL18487091 | 0.78 | LMNA (0.45) | LMNAHPGDKMT2ACNR2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2012500834-A | — | — | 2012-01-12 | — | — | JP | claimed |
| EP-2344456-A1 | NOVEL POTASSIUM CHANNEL BLOCKER | Xention Limited (GB) | 2011-07-20 | — | — | EP | claimed |
| EP-2344456-A1 | NOVEL POTASSIUM CHANNEL BLOCKER | Xention Limited (GB) | 2011-07-20 | — | — | EP | disclosed |