Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MCHR1 | Q99705 | 3/20 | 0.35 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.35 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25743441 | 0.93 | LMNA (0.51) | LMNAKDM4EHSD17B10ALDH1A1CHRM3 | |
| SCHEMBL25640538 | 0.93 | LMNA (0.51) | LMNAKDM4EHSD17B10ALDH1A1CHRM3 | |
| SCHEMBL25640465 | 0.93 | CYP2D6 (0.48) | LMNACYP2D6KDM4EHSD17B10ALDH1A1 | |
| SCHEMBL23924832 | 0.84 | LMNA (0.36) | LMNACYP2D6ALDH1A1TSHRNPSR1 | |
| SCHEMBL25743783 | 0.84 | LMNA (0.36) | LMNACYP2D6CHRM3NPSR1HTT | |
| SCHEMBL25203235 | 0.84 | LMNA (0.36) | LMNACYP2D6ALDH1A1TSHRNPSR1 | |
| SCHEMBL23943578 | 0.83 | LMNA (0.37) | LMNACYP2D6ALDH1A1CHRM3TSHR | |
| SCHEMBL23924923 | 0.83 | LMNA (0.37) | LMNACYP2D6CHRM3KCNJ1 | |
| SCHEMBL25190457 | 0.83 | LMNA (0.37) | LMNACYP2D6CHRM3KCNJ1 | |
| SCHEMBL25354316 | 0.81 | ALDH1A1 (0.41) | LMNAKDM4EALDH1A1CHRM3HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116969936-A | BCL-2 inhibitors | 百济神州有限公司 | 2023-10-31 | — | — | CN | disclosed |
| CN-116969937-A | BCL-2 inhibitors | 百济神州有限公司 | 2023-10-31 | — | — | CN | disclosed |
| CN-116802179-A | BCL-2 inhibitors | 百济神州有限公司 | 2023-09-22 | — | — | CN | disclosed |
| EP-4136084-A1 | BCL-2 INHIBITOR | BeiGene, Ltd. (KY) | 2023-02-22 | — | — | EP | disclosed |