Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.72 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.72 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.72 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.60 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.60 |
| ▸ | NPC1 | O15118 | 2/20 | 0.59 |
| ▸ | RAB9A | P51151 | 2/20 | 0.59 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.59 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.59 |
| ▸ | RORC | P51449 | 1/20 | 0.58 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | XBP1 | P17861 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | ESR1 | P03372 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL674439 | 0.89 | HDAC6 (0.82) | HDAC6HDAC3HDAC8PTGS1TRPV1 | |
| SCHEMBL3036039 | 0.85 | MAPT (0.70) | HDAC6HDAC3HDAC8PTGS1NPC1 | |
| SCHEMBL3036973 | 0.84 | MEN1 (0.61) | HDAC6HDAC3HDAC8NPC1RAB9A | |
| SCHEMBL7513604 | 0.83 | TRPV1 (0.83) | HDAC6HDAC3HDAC8PTGS1TRPV1 | |
| SCHEMBL3028810 | 0.81 | HDAC8 (0.67) | HDAC6HDAC8NPC1RAB9AMAPT | |
| SCHEMBL3034522 | 0.81 | MAPT (0.72) | HDAC6HDAC3HDAC8PTGS1NPC1 | |
| SCHEMBL3031316 | 0.80 | HDAC2 (0.74) | HDAC6HDAC8NPC1RAB9AMEN1 | |
| SCHEMBL3036033 | 0.80 | HDAC3 (0.59) | HDAC6HDAC3HDAC8NPC1RAB9A | |
| SCHEMBL14880225 | 0.79 | CES2 (0.64) | HDAC6HDAC3HDAC8PTGS1TRPV1 | |
| SCHEMBL3024518 | 0.79 | MEN1 (0.63) | HDAC6HDAC3HDAC8NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100216796-A1 | N-HYDROXY-NAPHTHALENE DICARBOXAMIDE AND N-HYDROXY-BIPHENYL-DICARBOXAMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | KATTAR SOLOMON | 2010-08-26 | — | — | US | claimed |
| EP-2205070-A1 | N-HYDROXY-NAPHTHALENE DICARBOXAMIDE AND N-HYDROXY-BIPHENYL-DICARBOXAMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2010-07-14 | — | — | EP | claimed |
| WO-2009045385-A1 | N-HYDROXY-NAPHTHALENE DICARBOXAMIDE AND N-HYDROXY-BIPHENYL-DICARBOXAMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | MERCK & CO., INC. (US) | 2009-04-09 | — | — | WO | claimed |
| US-20100216796-A1 | N-HYDROXY-NAPHTHALENE DICARBOXAMIDE AND N-HYDROXY-BIPHENYL-DICARBOXAMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | KATTAR SOLOMON | 2010-08-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100216796-A1 | N-HYDROXY-NAPHTHALENE DICARBOXAMIDE AND N-HYDROXY-BIPHENYL-DICARBOXAMIDE COMPOUNDS AS HISTONE DEACETYLASE INHIBITORS | BRDT, AADAC, ACIN1 | HDAC6 31/4885HDAC3 8/4885HDAC8 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.